Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds...

Full description

Bibliographic Details
Published in:Molecules
Main Author: Kim R.P.T.; Bihud V.; Bin Mohamad K.; Leong K.H.; Bin Mohamad J.; Bin Ahmad F.; Hazni H.; Kasim N.; Halim S.N.A.; Awang K.
Format: Article
Language:English
Published: 2013
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872841186&doi=10.3390%2fmolecules18010128&partnerID=40&md5=7732c94e36df53ab1b5883e88dd8f937
id 2-s2.0-84872841186
spelling 2-s2.0-84872841186
Kim R.P.T.; Bihud V.; Bin Mohamad K.; Leong K.H.; Bin Mohamad J.; Bin Ahmad F.; Hazni H.; Kasim N.; Halim S.N.A.; Awang K.
Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
2013
Molecules
18
1
10.3390/molecules18010128
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872841186&doi=10.3390%2fmolecules18010128&partnerID=40&md5=7732c94e36df53ab1b5883e88dd8f937
Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM. © 2013 by the authors.

14203049
English
Article
All Open Access; Gold Open Access; Green Open Access
author Kim R.P.T.; Bihud V.; Bin Mohamad K.; Leong K.H.; Bin Mohamad J.; Bin Ahmad F.; Hazni H.; Kasim N.; Halim S.N.A.; Awang K.
spellingShingle Kim R.P.T.; Bihud V.; Bin Mohamad K.; Leong K.H.; Bin Mohamad J.; Bin Ahmad F.; Hazni H.; Kasim N.; Halim S.N.A.; Awang K.
Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
author_facet Kim R.P.T.; Bihud V.; Bin Mohamad K.; Leong K.H.; Bin Mohamad J.; Bin Ahmad F.; Hazni H.; Kasim N.; Halim S.N.A.; Awang K.
author_sort Kim R.P.T.; Bihud V.; Bin Mohamad K.; Leong K.H.; Bin Mohamad J.; Bin Ahmad F.; Hazni H.; Kasim N.; Halim S.N.A.; Awang K.
title Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
title_short Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
title_full Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
title_fullStr Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
title_full_unstemmed Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
title_sort Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh
publishDate 2013
container_title Molecules
container_volume 18
container_issue 1
doi_str_mv 10.3390/molecules18010128
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872841186&doi=10.3390%2fmolecules18010128&partnerID=40&md5=7732c94e36df53ab1b5883e88dd8f937
description Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM. © 2013 by the authors.
publisher
issn 14203049
language English
format Article
accesstype All Open Access; Gold Open Access; Green Open Access
record_format scopus
collection Scopus
_version_ 1820775479911645184

Similar Items