Wound healing analysis of pectin/carboxymethyl cellulose/microfibrillated cellulose based composite scaffolds

In our previous study, we have synthesised pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds by lyophilisation and investigated its morphological, mechanical, thermal properties and tested their cytotoxicity. In this work, we explored the wound healing ability of pectin/c...

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Bibliographic Details
Published in:Materials Letters
Main Author: Ninan N.; Muthiah M.; Park I.-K.; Kalarikkal N.; Elain A.; Wui Wong T.; Thomas S.; Grohens Y.
Format: Article
Language:English
Published: Elsevier 2014
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903640058&doi=10.1016%2fj.matlet.2014.06.056&partnerID=40&md5=2d5f836605152e7f1a1f5a56920e7c0c
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Summary:In our previous study, we have synthesised pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds by lyophilisation and investigated its morphological, mechanical, thermal properties and tested their cytotoxicity. In this work, we explored the wound healing ability of pectin/carboxymethyl cellulose/microfibrillated cellulose based composite scaffolds. The pore size of the prepared scaffold was ideal for the growth of dermal fibroblasts. The in vivo studies conducted on Sprague Dawley rats showed that it could promote skin regeneration within ten days. The histological examination revealed excellent collagen deposition and complete re-epithelialisation in case of rats treated with composite, confirming its potential as excellent wound dressing material. © 2014 Elsevier B.V.
ISSN:0167577X
DOI:10.1016/j.matlet.2014.06.056