Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential

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Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential

Compounds 1-30 showed varying degree of α-glucosidase inhibition with IC50 values ranging between 187 and 420 μM. Compounds 1, 2, 3, 6, 8, 12, and 4 (IC50 = 187.7 ± 3.05, 203.4 ± 4.0, 240.7 ± 1.9, 252.9 ± 3.9, 285.2 ± 6.3, 399.07 ± 1.2, and 420.36 ± 5.6 μM, respectively) were found to be more active...

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Bibliographic Details
Published in:	Medicinal Chemistry Research
Main Author:	Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Format:	Article
Language:	English
Published:	Birkhauser Boston 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84934852218&doi=10.1007%2fs00044-014-1213-8&partnerID=40&md5=f9766e8be167226cebc66a658178de74

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