Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles

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Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles

Benzimidazole analogs 1-27 were synthesized, characterized by EI-MS and 1H NMR and their α-glucosidase inhibitory activities were found out experimentally. Compound 25, 19, 10 and 20 have best inhibitory activities with IC50 values 5.30 ± 0.10, 16.10 ± 0.10, 25.36 ± 0.14 and 29.75 ± 0.19 respectivel...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Mohamad M.H.; Wadood A.; Rahim F.; Saad S.M.; Rehman A.U.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959018778&doi=10.1016%2fj.bioorg.2016.02.004&partnerID=40&md5=f00e8b96e7b75766ee1842b5b42fdfa3

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