Synthesis of bis-indolylmethanes as new potential inhibitors of β-glucuronidase and their molecular docking studies
Thirty-two (32) bis-indolylmethane-hydrazone hybrids 1–32 were synthesized and characterized by 1HNMR, 13CNNMR and HREI-MS. All compounds were evaluated in vitro for β-glucuronidase inhibitory potential. All analogs showed varying degree of β-glucuronidase inhibitory potential ranging from 0.10 ± 0....
| Published in: | European Journal of Medicinal Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Masson s.r.l.
2018
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033591574&doi=10.1016%2fj.ejmech.2017.10.071&partnerID=40&md5=25123fa8f7fff0f74d5ed0f20b7ab3da |