Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

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Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

A new series of oxadiazole with thiadiazole moiety (6–27) were synthesized, characterized by different spectroscopic techniques and evaluated for β-glucuronidase inhibitory potential. Sixteen analogs such as 6, 7, 8, 9, 10, 12, 13, 14, 17, 18, 20, 23, 24, 25, 26 and 27 showed IC50 values in the rang...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Taha M.; Imran S.; Alomari M.; Rahim F.; Wadood A.; Mosaddik A.; Uddin N.; Gollapalli M.; Alqahtani M.A.; Bamarouf Y.A.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066996057&doi=10.1016%2fj.bmc.2019.05.049&partnerID=40&md5=ecd950b1a53d346832bbb97fc0a2db8b

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