Designing of promising medicinal scaffolds for Alzheimer's disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches

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Designing of promising medicinal scaffolds for Alzheimer's disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches

In the designed research work, a series of 2-furoyl piperazine based sulfonamide derivatives were synthesized as therapeutic agents to target the Alzheimer's disease. The structures of the newly synthesized compounds were characterized through spectral analysis and their inhibitory potential wa...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Hassan M.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shahzadi S.; Raza H.; Hussain G.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.-Y.; Malik A.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070881566&doi=10.1016%2fj.bioorg.2019.103138&partnerID=40&md5=c8e92e85fceb93ffadddfb004fa781fc

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