Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells

Mitragyna speciosa Korth (M. speciosa) has been widely used as a recreational product, however, there are growing concerns on the abuse potentials and toxicity of the plant. Several poisoning and fatal cases involving kratom and mitragynine have been reported but the underlying causes remain unclear...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Scientific Reports
المؤلف الرئيسي: Tay Y.L.; Amanah A.; Adenan M.I.; Wahab H.A.; Tan M.L.
التنسيق: مقال
اللغة:English
منشور في: Nature Research 2019
الوصول للمادة أونلاين:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077165762&doi=10.1038%2fs41598-019-56106-6&partnerID=40&md5=91025b95a9f9d5b0c5714a3795ec9692