Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers

Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers

The goal of this work was to synthesize some 4-chloro-N-(dimethylphenyl)butamide regio-isomers starting from dimethylated phenylamines and to examine their biofilm inhibition against Staphylococcus aureus and Escherichia coli strains along with hemolytic activity. The synthetic approach for the synt...

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Published in:Journal of the Chemical Society of Pakistan
Main Author: Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
Format: Article
Language:English
Published: Chemical Society of Pakistan 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100876566&partnerID=40&md5=3c233cc92b91389684d583f9213eefd6
id 2-s2.0-85100876566
spelling 2-s2.0-85100876566
Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
2020
Journal of the Chemical Society of Pakistan
42
4

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100876566&partnerID=40&md5=3c233cc92b91389684d583f9213eefd6
The goal of this work was to synthesize some 4-chloro-N-(dimethylphenyl)butamide regio-isomers starting from dimethylated phenylamines and to examine their biofilm inhibition against Staphylococcus aureus and Escherichia coli strains along with hemolytic activity. The synthetic approach for the synthesis of regio-isomers involved the reaction of 4-chlorobutanoyl chloride (1) with three different dimethylphenylamines (2a-c) in alkaline medium under vigorous shaking for 1-2 h under dynamic control of pH ranging from 9-10 to obtain the final products, 4-chloro-N-(dimethylphenyl)butamides (3a-c). The structural confirmation of these products was accomplished using IR, 1H-NMR, 13C-NMR and CHN analysis data. © 2020 Chemical Society of Pakistan. All rights reserved.
Chemical Society of Pakistan
2535106
English
Article
author Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
spellingShingle Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
author_facet Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
author_sort Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
title Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
title_short Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
title_full Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
title_fullStr Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
title_full_unstemmed Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
title_sort Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
publishDate 2020
container_title Journal of the Chemical Society of Pakistan
container_volume 42
container_issue 4
doi_str_mv
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100876566&partnerID=40&md5=3c233cc92b91389684d583f9213eefd6
description The goal of this work was to synthesize some 4-chloro-N-(dimethylphenyl)butamide regio-isomers starting from dimethylated phenylamines and to examine their biofilm inhibition against Staphylococcus aureus and Escherichia coli strains along with hemolytic activity. The synthetic approach for the synthesis of regio-isomers involved the reaction of 4-chlorobutanoyl chloride (1) with three different dimethylphenylamines (2a-c) in alkaline medium under vigorous shaking for 1-2 h under dynamic control of pH ranging from 9-10 to obtain the final products, 4-chloro-N-(dimethylphenyl)butamides (3a-c). The structural confirmation of these products was accomplished using IR, 1H-NMR, 13C-NMR and CHN analysis data. © 2020 Chemical Society of Pakistan. All rights reserved.
publisher Chemical Society of Pakistan
issn 2535106
language English
format Article
accesstype
record_format scopus
collection Scopus
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