| Summary: | Herbal medicines have been used in the treatment of male infertility since ancient times and are steadily regaining their popularity in recent decades. Studies on the efficacy of herbal medicine seem to be a rediscovery of traditional medicinal practices. This chapter discusses the various pharmacological effects of Withania somnifera, Panax ginseng, and Centella asiatica on semen quality and male reproductive hormones. The mechanism of actions of these herbs are discussed to highlight their effects on male reproduction. Future studies on male fertility treatment will need to further explore the synergistic effects of these herbal extracts with that of standard medicines. Additionally, studies focusing on the use of herbal components in ART would be beneficial to further develop the field. The efficacy of treatment in male infertility patients may be improved with advancements in herbal research, use of medical and herbal therapy in combination, along with the necessary lifestyle modifications. © 2021 Elsevier Inc. All rights reserved.
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