In vitro and in silico assessment of bioactivity properties and pharmacokinetic studies of new 3,5-disubstituted-1,2,4-triazoles
The synthesis of new, more potent, with the least side effects and economical drugs is essential for the modern world. In search of such drug candidates, a biologically important moiety 1,2,4-triazole was introduced to bioactive piperidine to acquire a list of compounds, 8a-8n, with subtle structura...
Published in: | Journal of Molecular Structure |
---|---|
Main Author: | Amjad H.; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Ashraf M.; Hussain S.; Shah S.A.A.; Imran S.; Shahid M.; Rasool A.; Rehman M.T.; Rehman A.U. |
Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2023
|
Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145590047&doi=10.1016%2fj.molstruc.2022.134720&partnerID=40&md5=5f373f0358001903c02d564936d54a37 |
Similar Items
-
Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi, et al.
Published: (2025) -
Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study
by: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Ashraf M.; Hussain S.; Saleem R.S.Z.; Rafique R.; Khan K.M.
Published: (2020) -
Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
by: Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
Published: (2018) -
Innovative cholinergic scaffolds, synthesis, and characterization of substituted 1,2,4-triazole-3-ylthio-N-acetamides and their in silico studies: supplement against neurodegenerative disease
by: Arfan M.; Siddiqui S.Z.; Abbasi M.A.; Aziz-ur-Rehman; Saad S.M.; Shah S.A.A.; Ashraf M.; Hussain S.; Ali F.; Solangi M.; Khan K.M.
Published: (2023) -
Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Muhammad S.; Raza H.; Shah S.A.A.; Shahid M.; Chaudhry A.R.; Kim S.J.
Published: (2025)