Drug-related problems among older people with dementia: A systematic review

Introduction: Dementia is a disorder that causes a decline of cognitive function, and it affects millions of people worldwide. Increased availability of medications used to treat dementia will inevitably increase the likelihood of drug-related problems (DRPs). Objective: This systematic review sough...

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Published in:Research in Social and Administrative Pharmacy
Main Author: Xue Qin Q.N.; Ming L.C.; Abd Wahab M.S.; Tan C.S.; Yuda A.; Hermansyah A.
Format: Review
Language:English
Published: Elsevier Inc. 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150381729&doi=10.1016%2fj.sapharm.2023.02.015&partnerID=40&md5=efbebe2379225186c136b1c22f7548db
id 2-s2.0-85150381729
spelling 2-s2.0-85150381729
Xue Qin Q.N.; Ming L.C.; Abd Wahab M.S.; Tan C.S.; Yuda A.; Hermansyah A.
Drug-related problems among older people with dementia: A systematic review
2023
Research in Social and Administrative Pharmacy
19
6
10.1016/j.sapharm.2023.02.015
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150381729&doi=10.1016%2fj.sapharm.2023.02.015&partnerID=40&md5=efbebe2379225186c136b1c22f7548db
Introduction: Dementia is a disorder that causes a decline of cognitive function, and it affects millions of people worldwide. Increased availability of medications used to treat dementia will inevitably increase the likelihood of drug-related problems (DRPs). Objective: This systematic review sought to identify DRPs due to medication misadventures, including adverse drug reactions (ADRs), and use of inappropriate medications, among patients with dementia or cognitive impairments. Methods: The included studies were retrieved from the electronic databases PubMed and SCOPUS, and a preprint platform (MedRXiv) which were searched from their inception through August 2022. The English-language publications that reported DRPs among dementia patients were included. The JBI Critical Appraisal Tool for quality assessment was used to evaluate the quality of studies included in the review. Results: Overall, 746 distinct articles were identified. Fifteen studies met the inclusion criteria and reported the most common DRPs, which comprised medication misadventures (n = 9), such as ADRs, inappropriate prescription use, and potentially inappropriate medication use (n = 6). Conclusion: This systematic review provides evidence that DRPs are prevalent among dementia patients, particularly the older people. It indicates that medication misadventures such as ADRs and inappropriate drug use, as well as potentially inappropriate medications, are the most prevalent DRPs among older people with dementia. Due to the small number of included studies, however, additional studies are required to improve comprehension about the issue. © 2023 Elsevier Inc.
Elsevier Inc.
15517411
English
Review
All Open Access; Green Open Access
author Xue Qin Q.N.; Ming L.C.; Abd Wahab M.S.; Tan C.S.; Yuda A.; Hermansyah A.
spellingShingle Xue Qin Q.N.; Ming L.C.; Abd Wahab M.S.; Tan C.S.; Yuda A.; Hermansyah A.
Drug-related problems among older people with dementia: A systematic review
author_facet Xue Qin Q.N.; Ming L.C.; Abd Wahab M.S.; Tan C.S.; Yuda A.; Hermansyah A.
author_sort Xue Qin Q.N.; Ming L.C.; Abd Wahab M.S.; Tan C.S.; Yuda A.; Hermansyah A.
title Drug-related problems among older people with dementia: A systematic review
title_short Drug-related problems among older people with dementia: A systematic review
title_full Drug-related problems among older people with dementia: A systematic review
title_fullStr Drug-related problems among older people with dementia: A systematic review
title_full_unstemmed Drug-related problems among older people with dementia: A systematic review
title_sort Drug-related problems among older people with dementia: A systematic review
publishDate 2023
container_title Research in Social and Administrative Pharmacy
container_volume 19
container_issue 6
doi_str_mv 10.1016/j.sapharm.2023.02.015
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150381729&doi=10.1016%2fj.sapharm.2023.02.015&partnerID=40&md5=efbebe2379225186c136b1c22f7548db
description Introduction: Dementia is a disorder that causes a decline of cognitive function, and it affects millions of people worldwide. Increased availability of medications used to treat dementia will inevitably increase the likelihood of drug-related problems (DRPs). Objective: This systematic review sought to identify DRPs due to medication misadventures, including adverse drug reactions (ADRs), and use of inappropriate medications, among patients with dementia or cognitive impairments. Methods: The included studies were retrieved from the electronic databases PubMed and SCOPUS, and a preprint platform (MedRXiv) which were searched from their inception through August 2022. The English-language publications that reported DRPs among dementia patients were included. The JBI Critical Appraisal Tool for quality assessment was used to evaluate the quality of studies included in the review. Results: Overall, 746 distinct articles were identified. Fifteen studies met the inclusion criteria and reported the most common DRPs, which comprised medication misadventures (n = 9), such as ADRs, inappropriate prescription use, and potentially inappropriate medication use (n = 6). Conclusion: This systematic review provides evidence that DRPs are prevalent among dementia patients, particularly the older people. It indicates that medication misadventures such as ADRs and inappropriate drug use, as well as potentially inappropriate medications, are the most prevalent DRPs among older people with dementia. Due to the small number of included studies, however, additional studies are required to improve comprehension about the issue. © 2023 Elsevier Inc.
publisher Elsevier Inc.
issn 15517411
language English
format Review
accesstype All Open Access; Green Open Access
record_format scopus
collection Scopus
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