Premature mortality and years of potential life lost from cardiovascular diseases: Protocol of a systematic review and meta-analysis

• Published in: PLoS ONE
• Main Author: Hasani W.S.R.; Muhamad N.A.; Maamor N.H.; Hanis T.M.; Wee C.X.; Hassan M.R.A.; Karim Z.A.; Musa K.I.
• Format: Article
• Language: English
• Published: Public Library of Science 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85158840708&doi=10.1371%2fjournal.pone.0284052&partnerID=40&md5=da5f83d964e2fb323547a7243408a496

Introduction Despite the burden of cardiovascular disease (CVD) continuing to increase globally, no comprehensive meta-analyses have been conducted quantifying premature CVD mortality. This paper reports the protocol for a systematic review and meta-analysis to derive updated estimates of premature CVD mortality. Methods and expected outputs This review will include the studies that reported premature CVD mortality based on standard premature mortality indicators, including years of life lost (YLL), age standardized mortality rate (ASMR) or standardised mortality ratio (SMR). PUBMED, Scopus, Web of Science (WoS), CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) will be used as the literature databases. The study selection as well as the evaluation of the quality of the included articles will be done independently by two reviewers. Pooled estimates of YLL, ASMR, and SMR will be computed by applying random-effects meta-analysis. Heterogeneity among selected studies will be assessed using the I2 statistic and Q statistic with associated p-values. A funnel plot analysis and Egger's test will be conducted to assess the potential impact of publication bias. Depending on data availability, we propose to conduct subgroup analyses by sex, geographic location, main CVD types, and study time. Reporting of our findings will follow the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Conclusion Our meta-analysis will provide a comprehensive synthesis of the available evidence on premature CVD mortality, which is a major public health concern worldwide. The results of this meta-analysis will have important implications for clinical practice and public health policy, providing insights into strategies to prevent and manage premature CVD mortality. © 2023 Rodzlan Hasani et al.