THE EFFECTS OF GENETIC VARIANTS TOWARDS WEIGHT AND BIOCHEMICAL CHANGES IN WEIGHT MANAGEMENT PROGRAM

• Published in: Journal of Health and Translational Medicine
• Main Author: Mohd Asmawi U.M.; Abdul Halim N.I.H.; Mohidin S.A.A.; Rajab N.; Kek T.L.; Salleh M.Z.; Mansyur M.; Md Nor N.
• Format: Article
• Language: English
• Published: Faculty of Medicine, University of Malaya 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172372907&doi=10.22452%2fjummec.sp2023no2.29&partnerID=40&md5=18c63b1422ad78d404617a752c536799

Genetic variation research indicates that 25% to 70% of body weight is determined by genetics. This study aimed tidentify the influence of genetic variants on weight and biochemical data changes in participants who underwena weight management program. A total of 30 obese participants were randomly assigned to either intervention ocontrol groups. The study consisted of three phases: Phase I (pre-assessment), Phase II (intervention phase), anPhase III (post-assessment). The intervention and control groups were selected using block randomisation. The studinvolved 30 participants aged between 31 and 41 with a BMI of 32.8 ± 6.12 kg/m2. By examining the available data, iis possible to observe trends suggesting potential associations between certain genotypes and weight changes. Twspecific variants, rs1726866 and rs1800497, significantly impacted glucose levels. Additionally, these two variantand another variant called rs1051168 were observed to influence cholesterol levels. These findings contribute tour understanding of the genetic factors that can potentially influence glucose and cholesterol metabolism anmay have implications for personalised approaches to managing glucose and cholesterol-related conditions towardweight management programs. © 2023, Faculty of Medicine, University of Malaya. All rights reserved.