Two new flavonols from Macaranga inermis pax & K.Hoffm
Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavono...
| Published in: | Natural Product Research |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis Ltd.
2025
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174606227&doi=10.1080%2f14786419.2023.2272783&partnerID=40&md5=5d69148aba8f7a8d9b157403eea54858 |
| Summary: | Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM). © 2023 Informa UK Limited, trading as Taylor & Francis Group. |
|---|---|
| ISSN: | 14786419 |
| DOI: | 10.1080/14786419.2023.2272783 |