TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia

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TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia

Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists have been examined for their efficacy in miti...

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Bibliographic Details
Published in:	Neurobiology of Disease
Main Author:	Poore C.P.; Hazalin N.A.M.N.; Wei S.; Low S.W.; Chen B.; Nilius B.; Hassan Z.; Liao P.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182873860&doi=10.1016%2fj.nbd.2024.106408&partnerID=40&md5=7c1fb1b993feb06eb855d715bacc3bfe

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