| Summary: | Two-pore channel (TPC) is an endolysosomal calcium channel implicated in numerous physiological processes and pathologies. Since no bibliometric studies have been conducted to evaluate the typical characteristics of TPC’s research, this study sought to pinpoint TPC’s global research trends and hotspots. The Scopus database was searched for TPC-related articles from 2000 to 2022. The data were analysed using Harzing’s Publish, Open Refine, and VOS viewer. In total, 292 TPC-related articles written in English were analysed. This study demonstrates that the publication rate of TPC has increased since their discovery in 2000 and will continue to increase until 2022. Over the past 22 years, research on TPC has focused on elucidating its function in calcium signalling, revealing its significance in a variety of physiological and pathological conditions. Yet, there are some research prospects for TPC that are currently understudied and warrant attention, notably in the context of autophagy, cancer, and COVID-19. © 2024 Universiti Putra Malaysia Press. All rights reserved.
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