Thymoquinone Reverses Homocysteine-Induced Endothelial Dysfunction via Inhibition of Endoplasmic Reticulum-Stress Induced Oxidative Stress Pathway

QR Code

Thymoquinone Reverses Homocysteine-Induced Endothelial Dysfunction via Inhibition of Endoplasmic Reticulum-Stress Induced Oxidative Stress Pathway

Hyperhomocysteinemia causes endoplasmic reticulum (ER) stress, which elevates reactive oxygen species (ROS) and induces endothelial dysfunction, the hallmark of cardiovascular diseases. Nigella sativa seeds contain thymoquinone (TQ), a cardioprotective bioactive component. Nevertheless, research on...

Full description

Bibliographic Details
Published in:	Sains Malaysiana
Main Author:	Sofiullah S.S.M.; Murugan D.D.; Muid S.A.; Seng W.Y.; Zamakshshari N.H.; Gan Q.F.; Patrick M.; Azis N.A.; Sirasanagandla S.R.; Woon C.K.
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189096887&doi=10.17576%2fjsm-2024-5303-09&partnerID=40&md5=a96ed0193588d5fed2f5974c6fe7e992

Similar Items

Bifidobacterium pseudocatenulatum ATCC 27919 exopolysaccharides induced autophagy and apoptosis against endoplasmic reticulum stress in Caco-2 cells
by: Zulkipli H.; Yaziz H.N.M.; Idorus M.Y.; Kadir S.H.S.A.; Musa M.; Khalil K.A.
Published: (2023)

Ficus deltoidea suppresses endothelial activation, inflammation, monocytes adhesion and oxidative stress via NF-κB and eNOS pathways in stimulated human coronary artery endothelial cells
by: Mohd Ariff A.; Abu Bakar N.A.; Abd Muid S.; Omar E.; Ismail N.H.; Ali A.M.; Mohd Kasim N.A.; Mohd Nawawi H.
Published: (2020)

Heavy Metal Exposure-Induced Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Role of Antioxidants
by: Ponnusamy B.; Veeraraghavan V.P.; Al-Huseini I.; Woon C.K.; Jayaraman S.; Sirasanagandla S.R.
Published: (2024)

Reversal of oxidative stress, cytokine toxicity and DNA fragmentation by quercetin in dizocilpine-induced animal model of Schizophrenia
by: 2-s2.0-85138753683
Published: (2022)

Cytokine factors present in dengue patient sera induces alterations of junctional proteins in human endothelial cells
by: 2-s2.0-84869100034
Published: (2012)

Ficus deltoidea suppresses endothelial activation, inflammation, monocytes adhesion and oxidative stress via NF-κB and eNOS pathways in stimulated human coronary artery endothelial cells
by: 2-s2.0-85089582076
Published: (2020)

Ursodeoxycholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein
by: Mohamed A.S.; Hanafi N.I.; Sheikh Abdul Kadir S.H.; Md Noor J.; Abdul Hamid Hasani N.; Ab Rahim S.; Siran R.
Published: (2017)

A study into salivary-based measurement of human stress subjected to ellestad stress test protocol
by: Lee Y.K.; Za'aba A.; Madzhi N.K.; Ahmad A.
Published: (2009)

Stress in music teaching: Identifying the level and sources of stress in the context of Malaysian national primary schools
by: 2-s2.0-77952225115
Published: (2010)

Stress and how it affects reproduction
by: 2-s2.0-33645686138
Published: (2006)

Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons
by: 2-s2.0-84886438363
Published: (2013)

Stress at the Helm: the Prevalence and Key Risk Factors of Occupational Stress Among Port Workers in the Port Terminal Industry
by: Yaakub N.; Razak N.F.A.; Baharuddin M.R.; Noor M.A.M.
Published: (2024)

Proteomics, oxidative stress and male infertility
by: Agarwal A.; Durairajanayagam D.; Halabi J.; Peng J.; Vazquez-Levin M.
Published: (2014)

Magnesium deficiency and oxidative stress: An update
by: 2-s2.0-84996483360
Published: (2016)

Proteomics, oxidative stress and male infertility
by: 2-s2.0-84904036565
Published: (2014)

Volatile components of the stressed liverwort conocephalum conicum
by: Ghani N.A.; Ludwiczuk A.; Ismail N.H.; Asakawa Y.
Published: (2016)

Enhancing Plant Resilience to Abiotic Stress: The Power of Biostimulants
by: Lau S.-E.; Lim L.W.T.; Hamdan M.F.; Chan C.; Saidi N.B.; Ong-Abdullah J.; Tan B.C.
Published: (2025)

Oxidative stress, testicular inflammatory pathways, and male reproduction
by: 2-s2.0-85115105953
Published: (2021)

Combating oxidative stress disorders with citrus flavonoid: Naringenin
by: 2-s2.0-85049942838
Published: (2018)

Dietary macronutrients and the aging liver sinusoidal endothelial cell
by: Cogger V.C.; Mohamad M.; Solon-Biet S.M.; Senior A.M.; Warren A.; O’Reilly J.N.; Tung B.T.; Svistounov D.; McMahon A.C.; Fraser R.; Raubenheimer D.; Holmes A.J.; Simpson S.J.; Le Couteur D.G.
Published: (2016)

Correlation between molar-incisor hypomineralization, stress, and family functioning
by: Brejawi M.; Venkiteswaran A.; Ergieg S.M.O.; Sabri B.M.
Published: (2022)

Effect of APC on killing of staphylococcus aureus by oxidative stress agents
by: Abdullah N.F.; Mohamad Hussain R.; Amom Z.
Published: (2016)

A Paro robot reduces the stressful effects of environmental noise
by: 2-s2.0-85033481683
Published: (2017)

Interaction with the paro robot may reduce psychophysiological stress responses
by: 2-s2.0-84964812810
Published: (2016)

Oxidative stress in human reproduction: Shedding light on a complicated Phenomenon
by: Agarwal A.; Sharma R.; Gupta S.; Harlev A.; Ahmad G.; du Plessis S.S.; Esteves S.C.; Wang S.M.; Durairajanayagam D.
Published: (2017)

Plant development, stress responses, and secondary metabolism under ethylene regulation
by: 2-s2.0-85149322565
Published: (2023)

Influential variables inducing aeronautical revenues at regional airports
by: Wan Mohamed W.M.; Jaffar A.; Shuib A.
Published: (2015)

Modal parameters of a hat-plate structure under residual stress effects
by: Peter C.; Afriani L.; Rani M.N.A.; Yunus M.A.; Bahari A.R.
Published: (2022)

Virtual Reality for Stress Reduction: Usability Insights into Exposure Environments and Relaxation Therapy
by: 2-s2.0-85219512099
Published: (2024)

Pressure-induced enhancement of mechanical performance in ZrC system
by: 2-s2.0-85124732078
Published: (2022)

The Use of Heart Rate Measures to Evaluate Stress Levels among Air Traffic Controllers
by: Rahman S.M.B.A.; Saini M.H.; Jaafar S.A.I.; Mustafa A.
Published: (2025)

Collapse settlement of unsaturated soil from effective stress and shear strength interaction of soil
by: Mohamed Jais I.B.; Md Noor M.J.
Published: (2019)

Association between Stress and Social Support Perceived among Undergraduate Health Sciences Student
by: 2-s2.0-85171555274
Published: (2023)

Curing behaviour of unsaturated polyester resin and interfacial shear stress of sugar palm fibre
by: 2-s2.0-85042762145
Published: (2017)

Establishment of rat brain endothelial cells susceptible to rat cytomegalovirus ALL-03 infection
by: Camalxaman S.-N.; Zeenathul N.A.; Quah Y.-W.; Loh H.-S.; Zuridah H.; Hani H.; Sheikh-Omar A.R.; Mohd-Azmi M.L.
Published: (2013)

Coping with stress: Exploring the lived experiences of English teachers who persist in Malaysian rural schools
by: 2-s2.0-85064125163
Published: (2019)

A study of job stress on job satisfaction among university staff in Malaysia: Empirical study
by: 2-s2.0-65349191964
Published: (2009)

Empirical model of ground-borne vibration induced by freight railway traffic
by: Lazi M.K.A.M.; Adnan M.A.; Sulaiman N.
Published: (2021)

Empirical model of ground-borne vibration induced by commuter railway traffic
by: Mohd Lazi M.K.A.; Adnan M.A.; Sulaiman N.
Published: (2021)

Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction
by: Wu L.E.; Meoli C.C.; Mangiafico S.P.; Fazakerley D.J.; Cogger V.C.; Mohamad M.; Pant H.; Kang M.-J.; Powter E.; Burchfield J.G.; Xirouchaki C.E.; Mikolaizak A.S.; Stöckli J.; Kolumam G.; Van Bruggen N.; Gamble J.R.; Le Couteur D.G.; Cooney G.J.; Andrikopoulos S.; James D.E.
Published: (2014)