4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined wit...
| Published in: | Natural Product Research |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis Ltd.
2024
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193989311&doi=10.1080%2f14786419.2024.2358526&partnerID=40&md5=c42c1e25dec7a084ab1cf942ee3af224 |
| Summary: | Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds 1-4 were assayed to MCF-7 and HeLa cells for their cytotoxic activity. Mesulepidotin A (1) showed high activity with an IC50 value of 1.59 and 1.41 µM, respectively. © 2024 Informa UK Limited, trading as Taylor & Francis Group. |
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| ISSN: | 14786419 |
| DOI: | 10.1080/14786419.2024.2358526 |