4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity

4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity

Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined wit...

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Published in:Natural Product Research
Main Author: Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
Format: Article
Language:English
Published: Taylor and Francis Ltd. 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193989311&doi=10.1080%2f14786419.2024.2358526&partnerID=40&md5=c42c1e25dec7a084ab1cf942ee3af224
id 2-s2.0-85193989311
spelling 2-s2.0-85193989311
Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
2024
Natural Product Research


10.1080/14786419.2024.2358526
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193989311&doi=10.1080%2f14786419.2024.2358526&partnerID=40&md5=c42c1e25dec7a084ab1cf942ee3af224
Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds 1-4 were assayed to MCF-7 and HeLa cells for their cytotoxic activity. Mesulepidotin A (1) showed high activity with an IC50 value of 1.59 and 1.41 µM, respectively. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
Taylor and Francis Ltd.
14786419
English
Article
All Open Access; Green Open Access
author Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
spellingShingle Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
author_facet Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
author_sort Tanjung M.; Aldin M.F.; Arif N.N.; Saputri R.D.; Ahmat N.; Tjahjandarie T.S.
title 4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
title_short 4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
title_full 4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
title_fullStr 4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
title_full_unstemmed 4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
title_sort 4-Propyl- and 4-phenylcoumarins from mesua lepidota T. Anderson and their cytotoxic activity
publishDate 2024
container_title Natural Product Research
container_volume
container_issue
doi_str_mv 10.1080/14786419.2024.2358526
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193989311&doi=10.1080%2f14786419.2024.2358526&partnerID=40&md5=c42c1e25dec7a084ab1cf942ee3af224
description Two new 4-phenylcoumarins, mesulepidotins A (1) and B (2), one new 4-propylcoumarin, mesulepidotin C (3), and one known 4-phenylcoumarin (4) were isolated from Mesua lepidota stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds 1-4 were assayed to MCF-7 and HeLa cells for their cytotoxic activity. Mesulepidotin A (1) showed high activity with an IC50 value of 1.59 and 1.41 µM, respectively. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
publisher Taylor and Francis Ltd.
issn 14786419
language English
format Article
accesstype All Open Access; Green Open Access
record_format scopus
collection Scopus
_version_ 1809678155048288256

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