Effect of Perfluorooctanoic Acid on Kidney Function in Diabetic and Non-Diabetic Male Guinea Pigs

• Published in: Iraqi Journal of Veterinary Medicine
• Main Author: Al-Aaraje Z.K.; Muhsain S.N.F.; Al-Saadi R.N.
• Format: Article
• Language: English
• Published: University of Baghdad, College of Veterinary Medicine 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85203028819&doi=10.30539%2fijvm.v47i2.1515&partnerID=40&md5=fe665c49cd119536e19a90154f345c95

Perfluorooctanoic acid (PFOA) is a synthetic fluor-surfactant chemical used widely in products that resist oil, heat, grease, stains, and water. It is also used in producing other fluoropolymers. The main sources of exposure to PFOA are water, soil, and animal-origin food (meat, fish, and dairy products). The aim of this study to evaluate the renal function following oral gavage of sub-lethal dose of PFOA in diabetic and non-diabetic guinea pigs. The experiment run for 4 weeks, total of 40 male guinea pigs, (Cavia porcellus), were randomly selected and grouped into four equal groups. The first group (G1) served as the negative control; 2nd group (G2) alloxan induced diabetic, 3rd group (G3) non-diabetic was exposed to PFOA at 100 mg/kg BW orally/daily and 4th Group (G4) was diabetic guinea pig exposed to PFOA at 100 mg/kg BW orally/daily. Serum creatinine and histopathological alterations in the kidney tissue were evaluated. Serum creatinine concentrations were significantly increased (P<0.05) in G3 and G4 exposed to PFOA. High serum creatinine levels were suggesting impairment in kidney function. Impaired kidney function was confirmed through histopathological changes such as glomerular atrophy, severe necrosis, and degeneration of renal tubular epithelium in guinea pigs that received PFOA in G3 and G4. In conclusion, the results confirmed that PFOA was associated with renal damage and elevated creatinine concentrations in diabetic and non-diabetic animals since PFOA itself can contribute to diabetes. © 2024 American Society of Plant Biologists. All rights reserved.