New halogenated chalcones as potential anti-inflammatory agents: A comprehensive In-Silico, In-Vitro, and In-Vivo study with ADME profiling

QR Code

New halogenated chalcones as potential anti-inflammatory agents: A comprehensive In-Silico, In-Vitro, and In-Vivo study with ADME profiling

This study explored the anti-inflammatory potential of halogenated chalcone derivatives using in-silico, in-vitro and in-vivo models. The synthesized compounds were assessed for their ability to inhibit reactive oxygen species (ROS) production and their interaction with the cyclooxygenase-1 (COX-1)...

书目详细资料
发表在:	Journal of Molecular Structure
主要作者:	Iqtadar R.; Naz A.; Shah S.A.A.; Ali S.; Abdullah S.
格式:	文件
语言:	English
出版:	Elsevier B.V. 2025
在线阅读:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212427663&doi=10.1016%2fj.molstruc.2024.141055&partnerID=40&md5=b58724c26ca202294ee4b0ab908b7606

相似书籍

Dexibuprofen loaded into nanoemulsion based gel for topical application – In vitro characterization and in vivo anti-inflammatory evaluation
由: 2-s2.0-85210372378
出版: (2025)

Virtual screening, ADME study, and molecular dynamic simulation of chalcone and flavone derivatives as 5-Lipoxygenase (5-LO) inhibitor
由: 2-s2.0-85081355590
出版: (2020)

Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship insight, in vitro and in silico approaches
由: 2-s2.0-85193900160
出版: (2024)

Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid Receptor
由: Rashid S.; Anjum S.; Ahmad A.; Nadeem R.; Ahmed M.; Shah S.A.A.; Abdullah M.; Zia K.; Ul-Haq Z.
出版: (2022)

Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: A promising approach to develop potential anti-diabetic agents
由: 2-s2.0-85209950182
出版: (2024)

Discovery of imidazopyridine derived oxadiazole-based thiourea derivatives as potential anti-diabetic agents: Synthesis, in vitro antioxidant screening and in silico molecular modeling approaches
由: 2-s2.0-85167451003
出版: (2023)

Repetitive cryotherapy attenuates the in vitro and in vivo mononuclear cell activation response
由: Lindsay A.; Othman M.I.; Prebble H.; Davies S.; Gieseg S.P.
出版: (2016)

In vitro and in vivo evaluation of pectin/copper exchanged faujasite composite membranes
由: Ninan N.; Muthiah M.; Park I.-K.; Elain A.; Wong T.W.; Thomas S.; Grohens Y.
出版: (2015)

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways
由: Jabbar A.A.J.; Abdul-Aziz Ahmed K.; Abdulla M.A.; Abdullah F.O.; Salehen N.A.; Mothana R.A.; Houssaini J.; Hassan R.R.; Hawwal M.F.; Fantoukh O.I.; Hasson S.
出版: (2024)

New piperidinyl heterocyclic azoles acquired through Li(I)-catalyzed reactions: Anti-enzymatic, ADME and computational studies
由: 2-s2.0-85182735120
出版: (2024)

Ab initio quantum chemical studies of six-center bond exchange reactions among halogen and halogen halide molecules
由: 2-s2.0-38049116005
出版: (2007)

Faujasites incorporated tissue engineering scaffolds for wound healing: In vitro and in vivo analysis
由: Ninan N.; Muthiah M.; Park I.-K.; Elain A.; Wong T.W.; Thomas S.; Grohens Y.
出版: (2013)

Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
由: 2-s2.0-84905899348
出版: (2014)

Evaluation of moringa oleifera aqueous extract for antinoCICeptive and anti-inflammatory activities in animal models
由: Sulaiman M.R.; Zakaria Z.A.; Bujarimin A.S.; Somchit M.N.; Israf D.A.; Moin S.
出版: (2008)

Benzothiazole Derived Ether Hybrids as Potent Anti-Thymidine Phosphorylase Agents: Synthesis, In Vitro, and Computational Investigations
由: 2-s2.0-85219557864
出版: (2025)

Smart nanocrystals of artemether: Fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation
由: 2-s2.0-85003698530
出版: (2016)

A new xanthone from Garcinia cowa Roxb. and its anti-inflammatory activity
由: Dewi I.P.; Dachriyanus; Aldi Y.; Ismail N.H.; Osman C.P.; Putra P.P.; Wahyuni F.S.
出版: (2025)

A new xanthone from Garcinia cowa Roxb. and its anti-inflammatory activity
由: Dewi, et al.
出版: (2025)

A new xanthone from Garcinia cowa Roxb. and its anti-inflammatory activity
由: 2-s2.0-85217734377
出版: (2025)

Antinociceptive, anti-inflammatory and antipyretic properties of an aqueous extract of Corchorus capsularis leaves in experimental animal models
由: Zakaria Z.A.; Kumar G.H.; Mohd. Nor R.N.S.R.; Sulaiman M.R.; Fatimah C.A.; Jais A.M.M.; Somchit M.N.; Ismail M.S.
出版: (2009)

Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents
由: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Ahmad I.; Malik R.; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.
出版: (2017)

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
由: 2-s2.0-85071689548
出版: (2019)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
由: 2-s2.0-85191352219
出版: (2024)

Multifunctional hydrolysates from kenaf (Hibiscus cannabinus L.) seed protein with high antihypertensive activity in vitro and in vivo
由: Zaharuddin N.D.; Hanafi M.A.; Chay S.Y.; Hussin F.S.; Auwal S.M.; Zarei M.; Sarbini S.R.; Wan Ibadullah W.Z.; Karim R.; Saari N.
出版: (2021)

Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: Formulation optimization, characterization, analgesic and acute toxicity studies
由: 2-s2.0-85028647685
出版: (2017)

Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors
由: 2-s2.0-85169592392
出版: (2023)

In vivo acute toxicity and anti-gastric evaluation of a novel dichloro Schiff base: Bax and HSP70 alteration
由: 2-s2.0-85079327382
出版: (2020)

Synthesis, characterization, in-vitro and in-silico therapeutic studies of cinnamaldehyde derivatives
由: 2-s2.0-85204950204
出版: (2025)

Cubosomes hydrogel containing silver based organometallic compounds for enhanced wound healing of burns: In vitro and in vivo studies
由: 2-s2.0-85208764071
出版: (2024)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
由: 2-s2.0-85076239103
出版: (2020)

Understanding the mode-of-action of Cassia auriculata via in silico and in vivo studies towards validating it as a long term therapy for type II diabetes
由: 2-s2.0-84979768784
出版: (2017)

Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives
由: 2-s2.0-85017157762
出版: (2017)

Synthesis, Spectroscopic Characterization, DFT, Molecular Docking, Catechol Oxidase Activity, and Anti-SARS-CoV-2 of Acylhydrazone Derivatives
由: Anouar E.H.; Filali I.; Shah S.A.A.; Karrouchi K.
出版: (2025)

Synthesis, anti-diabetic and in silico QSAR analysis of flavone hydrazide Schiff base derivatives
由: 2-s2.0-85114800864
出版: (2022)

Recent Advances in Using Adsorbent Derived from Agricultural Waste for Antibiotics and Non-Steroidal Anti-Inflammatory Wastewater Treatment: A Review
由: 2-s2.0-85160329511
出版: (2023)

The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies
由: Khan K.M.; Mesaik M.A.; Abdalla O.M.; Rahim F.; Soomro S.; Halim S.A.; Mustafa G.; Ambreen N.; Khalid A.S.; Taha M.; Perveen S.; Alam M.T.; Hameed A.; Ul-Haq Z.; Ullah H.; Rehman Z.U.; Siddiqui R.A.; Voelter W.
出版: (2016)

Synthesis, characterization, in-vitro pharmacological assessment and molecular docking studies of trigonelline derivatives
由: Singh N.; Yadav S.S.; Kumar S.; Narasihman B.; Ramasamy K.; Lim S.M.; Shah S.A.A.
出版: (2025)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
由: 2-s2.0-85146025150
出版: (2023)

Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions
由: 2-s2.0-84943771420
出版: (2015)

Metabolomics-based profiling with chemometric approach to identify bioactive compounds in Salacca zalacca fruits extracts and in silico molecular docking
由: 2-s2.0-85101359053
出版: (2021)