Hemocompatible chitosan nanoparticle diallyl disulfide-modified polysulfone hollow fibre membrane with antithrombotic and antioxidant properties for haemodialysis applications

• Published in: International Journal of Biological Macromolecules
• Main Author: Zailani M.Z.; Jaafar J.; Goh P.S.; Kadir S.H.S.A.; Othman M.H.D.; Ahmad S.N.A.; Raharjo Y.; Yudaniayanti I.S.; Santoso D.; Ismail A.F.
• Format: Article
• Language: English
• Published: Elsevier B.V. 2025
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85217923854&doi=10.1016%2fj.ijbiomac.2025.141231&partnerID=40&md5=5ae701968cf7d77ddf5eeed265860aa5

The study aims to enhance the biocompatibility of haemodialysis membranes to reduce mortality risks in end-stage renal disease (ESRD) patients by addressing oxidative stress and thrombus formation. A novel Chitosan Diallyl Disulfide Nanoparticle (CNP/DADS) complex was immobilised into PSF membranes at various concentrations. The most optimal membrane, with 0.3 wt% CNP, demonstrated the highest KUF of 116 mL/m2.h.mmHg, 95.7 % BSA rejection, and significant urea, creatinine, and lysozyme clearance rates. This was attributed to increased hydrophilicity, improved morphological structure with higher porosity, and a thinner membrane skin layer. However, CNP/DADS-immobilised PSF HFM showed reduced performance due to denser morphological structures. Despite this, CNP/DADS-immobilised membranes met high-flux standards and exhibited enhanced biocompatibility, low haemolysis percentage, reduced protein adsorption and platelet adhesion, and less complement activation. They also significantly prolonged clotting times (P < 0.001) and demonstrated superior antioxidant activity against nitric oxide and hydrogen peroxide compared to CNP alone. Overall, the study suggests the successful development of PSF-based haemodialysis membranes with excellent antioxidant and antithrombotic properties, which is deemed suitable for safely and effectively removing uremic toxins during haemodialysis therapy. © 2025 Elsevier B.V.