| Summary: | This article discusses Blockchain and Generative AI in healthcare, including their uses, difficulties, and solutions. Blockchain technology improves EHR security, privacy, and interoperability, while smart contracts streamline supply chain management and administrative procedures. Blockchain verifies and secures IoT data, improving medical care and treatment, according to case studies. Generative AI systems like ChatGPT have transformed healthcare by personalizing therapy, diagnostics, and predictive analytics. AI systems can examine massive databases to diagnose diseases early, anticipate dangers, and personalize therapies. By providing timely information, boosting treatment adherence, and giving continuous support, AI-powered virtual health assistants have enhanced patient involvement. Generative AI has additionally enhanced medical research and drug development, cutting the time and expense of introducing new medicines. Generative AI and Blockchain provide safe patient data storage, high-quality AI training datasets, and efficient healthcare operations. Scalability, energy usage, and interoperability issues remain. Scalable Blockchain designs and standardized data integration and exchange protocols are suggested by this study. These technologies could improve medical research and therapy by making them safer, more effective, and more individualized. © The Author(s) 2025.
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