Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies

QR Code

Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies

We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and butyrylcholinesterase (BchE) inhibition activities. All the syn...

Full description

Bibliographic Details
Published in:	Molecules
Main Author:	2-s2.0-85093694209
Format:	Article
Language:	English
Published:	MDPI AG 2020
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093694209&doi=10.3390%2fmolecules25204828&partnerID=40&md5=e67ece50533c78c90d8a2924bfca506e

Similar Items

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
by: 2-s2.0-85189482031
Published: (2024)

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
by: 2-s2.0-84940020718
Published: (2015)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
by: 2-s2.0-85173583185
Published: (2023)

Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer’s Disease
by: 2-s2.0-85141550803
Published: (2022)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
by: 2-s2.0-85191352219
Published: (2024)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
by: 2-s2.0-85144315169
Published: (2023)

Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents
by: 2-s2.0-85204151475
Published: (2024)

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies
by: 2-s2.0-84962360234
Published: (2016)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
by: 2-s2.0-85219522570
Published: (2025)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
by: Taha, et al.
Published: (2025)

Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study
by: 2-s2.0-85032929001
Published: (2017)

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
by: 2-s2.0-85145589794
Published: (2023)

Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer’s disease
by: 2-s2.0-85136203736
Published: (2022)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
by: 2-s2.0-85044438335
Published: (2018)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: 2-s2.0-85074862203
Published: (2020)

Synthesis, biological evaluation, molecular docking and dynamic simulation of novel benzofuran derivatives as potential agents against Alzheimer's disease
by: 2-s2.0-85206074124
Published: (2025)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
by: 2-s2.0-85101323909
Published: (2021)

Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship insight, in vitro and in silico approaches
by: 2-s2.0-85193900160
Published: (2024)

2-(2'-pyridyl) benzimidazole analogs and their ß-glucuronidase inhibitory activity
by: 2-s2.0-84953331043
Published: (2015)

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study
by: 2-s2.0-85217236617
Published: (2025)

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study
by: Mukhliss L.; Taha M.; Rahim F.; Adalat B.; Ajmal A.; Wadood A.; Uddin N.; Khan K.M.; Ali Shah S.A.
Published: (2025)

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study
by: Mukhliss, et al.
Published: (2025)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: 2-s2.0-85179140411
Published: (2024)

Designing of promising medicinal scaffolds for Alzheimer's disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches
by: 2-s2.0-85070881566
Published: (2019)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
by: 2-s2.0-84979210899
Published: (2016)

Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: A promising approach to develop potential anti-diabetic agents
by: 2-s2.0-85209950182
Published: (2024)

Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights
by: 2-s2.0-85053905014
Published: (2018)

Metabolomics-based profiling with chemometric approach to identify bioactive compounds in Salacca zalacca fruits extracts and in silico molecular docking
by: 2-s2.0-85101359053
Published: (2021)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
by: 2-s2.0-85042298379
Published: (2018)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
by: 2-s2.0-84946228073
Published: (2015)

Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole-Benzothiazine Skeleton
by: 2-s2.0-85097212373
Published: (2020)

Synthesis, Spectroscopic Characterization, DFT, Molecular Docking, Catechol Oxidase Activity, and Anti-SARS-CoV-2 of Acylhydrazone Derivatives
by: 2-s2.0-85201948344
Published: (2025)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: 2-s2.0-85087130142
Published: (2020)

Synthesis, Spectroscopic Characterization, DFT, Molecular Docking, Catechol Oxidase Activity, and Anti-SARS-CoV-2 of Acylhydrazone Derivatives
by: Anouar E.H.; Filali I.; Shah S.A.A.; Karrouchi K.
Published: (2025)

Molecular docking and molecular dynamic simulations of apoptosis proteins with potential anticancer compounds present in Clinacanthus nutans extract using gas chromatography–mass spectrometry
by: 2-s2.0-85135177285
Published: (2023)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
by: 2-s2.0-84928815461
Published: (2015)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
by: 2-s2.0-85074173138
Published: (2019)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
by: 2-s2.0-85029659650
Published: (2017)

Streptozotocin mechanisms and its role in rodent models for Alzheimer’s disease
by: 2-s2.0-85144019319
Published: (2023)

Synthesis, characterization, in-vitro pharmacological assessment and molecular docking studies of trigonelline derivatives
by: Singh N.; Yadav S.S.; Kumar S.; Narasihman B.; Ramasamy K.; Lim S.M.; Shah S.A.A.
Published: (2025)