Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
Hybrid bis-coumarin derivatives 1–18 were synthesized and evaluated for their in vitro urease inhibitory potential. All compounds showed outstanding urease inhibitory potential with IC50 value (The half maximal inhibitory concentration) ranging in between 0.12 SD 0.01 and 38.04 SD 0.63 µM (SD standa...
出版年: | Bioorganic Chemistry |
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第一著者: | |
フォーマット: | 論文 |
言語: | English |
出版事項: |
Academic Press Inc.
2019
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オンライン・アクセス: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071689548&doi=10.1016%2fj.bioorg.2019.103235&partnerID=40&md5=7f6c163ed9319ed5d2e11fe81676b814 |