Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives

Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives

A number of novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-Oxadiazole derivatives (6a-l) have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids (1a-l) as precursors, 5-substituted-1,3,4-Oxadiazol-2-thiols...

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الحاوية / القاعدة:Pakistan Journal of Pharmaceutical Sciences
المؤلف الرئيسي: 2-s2.0-85052853089
التنسيق: مقال
اللغة:English
منشور في: Pakistan Journal of Pharmaceutical Sciences 2018
الوصول للمادة أونلاين:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052853089&partnerID=40&md5=f8fda025e37162e15c4edff5ccc05103
id Aziz-ur-Rehman; Siddiqa A.; Abbasi M.A.; Siddiqui S.Z.; Khan S.G.; Rasool S.; Ali Shah S.A.
spelling Aziz-ur-Rehman; Siddiqa A.; Abbasi M.A.; Siddiqui S.Z.; Khan S.G.; Rasool S.; Ali Shah S.A.
2-s2.0-85052853089
Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
2018
Pakistan Journal of Pharmaceutical Sciences
31
5

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052853089&partnerID=40&md5=f8fda025e37162e15c4edff5ccc05103
A number of novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-Oxadiazole derivatives (6a-l) have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids (1a-l) as precursors, 5-substituted-1,3,4-Oxadiazol-2-thiols (4a-l) were yielded in good amounts. The derivatives, 4a-l, were subjected to electrophilic substitution reaction on stirring with 6-bromo-3,4-methylenedioxybenzyl chloride (5) in DMF to synthesize the required compounds. All the synthesized molecules were well characterized by IR, 1 H-NMR, 13 C-NMR and EIMS spectral data and evaluated for antibacterial activity against some bacterial strains of Gram-bacteria. The molecule, 6d, demonstrated the best activity among all the synthesized molecules exhibiting weak to moderate inhibition potential. © 2018 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.
Pakistan Journal of Pharmaceutical Sciences
1011601X
English
Article
author 2-s2.0-85052853089
spellingShingle 2-s2.0-85052853089
Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
author_facet 2-s2.0-85052853089
author_sort 2-s2.0-85052853089
title Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
title_short Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
title_full Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
title_fullStr Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
title_full_unstemmed Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
title_sort Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
publishDate 2018
container_title Pakistan Journal of Pharmaceutical Sciences
container_volume 31
container_issue 5
doi_str_mv
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052853089&partnerID=40&md5=f8fda025e37162e15c4edff5ccc05103
description A number of novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-Oxadiazole derivatives (6a-l) have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids (1a-l) as precursors, 5-substituted-1,3,4-Oxadiazol-2-thiols (4a-l) were yielded in good amounts. The derivatives, 4a-l, were subjected to electrophilic substitution reaction on stirring with 6-bromo-3,4-methylenedioxybenzyl chloride (5) in DMF to synthesize the required compounds. All the synthesized molecules were well characterized by IR, 1 H-NMR, 13 C-NMR and EIMS spectral data and evaluated for antibacterial activity against some bacterial strains of Gram-bacteria. The molecule, 6d, demonstrated the best activity among all the synthesized molecules exhibiting weak to moderate inhibition potential. © 2018 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.
publisher Pakistan Journal of Pharmaceutical Sciences
issn 1011601X
language English
format Article
accesstype
record_format scopus
collection Scopus
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