Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension

Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension

Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common – affecting at least one third of the world’s adult population – but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to t...

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發表在:Hereditas
主要作者: 2-s2.0-85059888916
格式: Article
語言:English
出版: BioMed Central Ltd 2019
在線閱讀:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059888916&doi=10.1186%2fS41065-019-0080-1&partnerID=40&md5=caf9af594da494bdef0b4f6e4e643d2b
id Hoh B.-P.; Rahman T.A.; Yusoff K.
spelling Hoh B.-P.; Rahman T.A.; Yusoff K.
2-s2.0-85059888916
Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
2019
Hereditas
156

10.1186/S41065-019-0080-1
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059888916&doi=10.1186%2fS41065-019-0080-1&partnerID=40&md5=caf9af594da494bdef0b4f6e4e643d2b
Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common – affecting at least one third of the world’s adult population – but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to therapy, contributed by secondary hypertension but more commonly the hitherto inability to precisely predict response to specific antihypertensive agents. Population and individual genomics information could be useful in guiding the selection and predicting the response to treatment – an approach known as precision medicine. However this cannot be achieved without the knowledge of genetic variations that influence blood pressure (BP). A number of evolutionary factors including population demographics and forces of natural selection may be involved. This article explores some ideas on how natural selection influences BP regulation in ethnically and geographically diverse populations that could lead to them being susceptible to HTN. We explore how such evolutionary factors could impact the implementation of precision medicine in HTN. Finally, in order to ensure the success of precision medicine in HTN, we call for more initiatives to understand the genetic architecture within and between diverse populations with ancestry from different parts of the world, and to precisely classify the intermediate phenotypes of HTN. © The Author(s). 2019.
BioMed Central Ltd
180661
English
Article
All Open Access; Gold Open Access; Green Open Access
author 2-s2.0-85059888916
spellingShingle 2-s2.0-85059888916
Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
author_facet 2-s2.0-85059888916
author_sort 2-s2.0-85059888916
title Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
title_short Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
title_full Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
title_fullStr Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
title_full_unstemmed Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
title_sort Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
publishDate 2019
container_title Hereditas
container_volume 156
container_issue
doi_str_mv 10.1186/S41065-019-0080-1
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059888916&doi=10.1186%2fS41065-019-0080-1&partnerID=40&md5=caf9af594da494bdef0b4f6e4e643d2b
description Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common – affecting at least one third of the world’s adult population – but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to therapy, contributed by secondary hypertension but more commonly the hitherto inability to precisely predict response to specific antihypertensive agents. Population and individual genomics information could be useful in guiding the selection and predicting the response to treatment – an approach known as precision medicine. However this cannot be achieved without the knowledge of genetic variations that influence blood pressure (BP). A number of evolutionary factors including population demographics and forces of natural selection may be involved. This article explores some ideas on how natural selection influences BP regulation in ethnically and geographically diverse populations that could lead to them being susceptible to HTN. We explore how such evolutionary factors could impact the implementation of precision medicine in HTN. Finally, in order to ensure the success of precision medicine in HTN, we call for more initiatives to understand the genetic architecture within and between diverse populations with ancestry from different parts of the world, and to precisely classify the intermediate phenotypes of HTN. © The Author(s). 2019.
publisher BioMed Central Ltd
issn 180661
language English
format Article
accesstype All Open Access; Gold Open Access; Green Open Access
record_format scopus
collection Scopus
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