Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors

QR Code

Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors

α-Glucosidase inhibitors (AGIs) are used as medicines for the treatment of diabetes mellitus. The α-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars. The process results in an increase in blood sugar levels. AGIs slow down the dig...

書目詳細資料
發表在:	Molecules
主要作者:	2-s2.0-85112329694
格式:	Article
語言:	English
出版:	MDPI AG 2021
在線閱讀:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112329694&doi=10.3390%2fmolecules26164760&partnerID=40&md5=bc2b6a585ad05ed6048fce3d82640811

相似書籍

Development of benzimidazolium salt-based cubosome hydrogel for topical treatment of burns
由: 2-s2.0-85217012735
出版: (2025)

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
由: 2-s2.0-85185155619
出版: (2024)

Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions
由: 2-s2.0-84943771420
出版: (2015)

Evaluation of 2-indolcarbohydrazones as potent α-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions
由: 2-s2.0-84942794211
出版: (2015)

Synthesis and biological evaluation of novel coumarin derivatives bearing sulfonamide moiety as potent α-glucosidase inhibitors
由: Alsukor A.; Inayatsyah N.A.; Ridhwan M.J.M.; Kasim N.; Imran S.
出版: (2025)

Synthesis and Molecular Docking Study of Hydrazone Schiff Bases of α-Naphthalene-Containing Alkyl Phenyl Ether Fragment as Potent α-Amylase and α-Glucosidase Inhibitors
由: 2-s2.0-85208551606
出版: (2024)

New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in silico study
由: 2-s2.0-85140093344
出版: (2022)

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats
由: 2-s2.0-85102849446
出版: (2021)

Synthesis of new oxadiazole derivatives as α-glucosidase inhibitors
由: 2-s2.0-84937512790
出版: (2015)

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies
由: 2-s2.0-84948649641
出版: (2016)

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach
由: 2-s2.0-85191891273
出版: (2024)

Insight into the Structure and Physicochemical Properties of Potent Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer’s Disease Drugs
由: Yusof N.I.S.M.; Awaluddin N.A.; Fauzi F.M.
出版: (2023)

Novel thiosemicarbazide-oxadiazole hybrids as unprecedented inhibitors of yeast α-glucosidase and in silico binding analysis
由: 2-s2.0-84964523904
出版: (2016)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
由: 2-s2.0-85074173138
出版: (2019)

Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer
由: 2-s2.0-85197352734
出版: (2024)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
由: 2-s2.0-85101323909
出版: (2021)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
由: 2-s2.0-85144315169
出版: (2023)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
由: 2-s2.0-84979210899
出版: (2016)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
由: 2-s2.0-84928815461
出版: (2015)

5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes
由: 2-s2.0-85016039331
出版: (2017)

The functionality of α-kafirin promoter and α-kafirin signal peptide
由: Liu G.; Lamont K.C.; Ahmad N.; Tomkins A.; Mudge S.R.; Gilding E.K.; Godwin I.D.
出版: (2017)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
由: 2-s2.0-85042298379
出版: (2018)

Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition
由: 2-s2.0-84863985161
出版: (2012)

Antioxidant and α-glucosidase inhibitory constituents from Hornstedtia species of Malaysia
由: Hashim S.E.; Sirat H.M.; Yen K.H.; Ismail I.S.; Matsuki S.N.
出版: (2015)

Synthesis of Functionalized Thiophene Based Pyrazole Amides via Various Catalytic Approaches: Structural Features through Computational Applications and Nonlinear Optical Properties
由: 2-s2.0-85122264577
出版: (2022)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
由: 2-s2.0-85146025150
出版: (2023)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
由: 2-s2.0-85044438335
出版: (2018)

Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study
由: 2-s2.0-85087042710
出版: (2020)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
由: 2-s2.0-84984780886
出版: (2016)

Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor
由: 2-s2.0-85084696332
出版: (2020)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
由: 2-s2.0-84946228073
出版: (2015)

Molecular Modeling and Synthesis of Indoline-2,3-dione-Based Benzene Sulfonamide Derivatives and Their Inhibitory Activity against α-Glucosidase and α-Amylase Enzymes
由: 2-s2.0-85154584205
出版: (2023)

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies
由: 2-s2.0-84944728488
出版: (2015)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
由: 2-s2.0-85064857181
出版: (2019)

A review of bisindolylmethane as an important scaffold for drug discovery
由: 2-s2.0-84953775700
出版: (2015)

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4‑methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl) acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study
由: 2-s2.0-85073287972
出版: (2019)

Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies
由: 2-s2.0-84976472588
出版: (2016)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
由: 2-s2.0-85219522570
出版: (2025)

Knowledge Discovery from the Digital Library’s Contents: Bangladesh Perspective
由: 2-s2.0-85121933752
出版: (2021)

Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α-glucosidase inhibitory activity, and in silico studies
由: 2-s2.0-85021402072
出版: (2017)