Challenges and Complications of Poly(Lactic-Co-Glycolic Acid)-Based Long-Acting Drug Product Development

QR Code

Challenges and Complications of Poly(Lactic-Co-Glycolic Acid)-Based Long-Acting Drug Product Development

Poly(lactic-co-glycolic acid) (PLGA) is one of the preferred polymeric inactive ingredients for long-acting parenteral drug products that are constituted of complex formulations. Despite over 30 years of use, there are still many challenges faced by researchers in formulation-related aspects pertain...

Full description

Bibliographic Details
Published in:	Pharmaceutics
Main Author:	2-s2.0-85126996246
Format:	Review
Language:	English
Published:	MDPI 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126996246&doi=10.3390%2fpharmaceutics14030614&partnerID=40&md5=872ecf7076ffbdb1e2f0bcf0daa053e3

Similar Items

Preparation and characterization of poly(ethylene carbonate)/poly(lactic acid) blends
by: 2-s2.0-85041124959
Published: (2018)

Probiotic potential of lactic acid bacteria from fermented Malaysian food or milk products
by: Ramasamy K.; Rahman N.Z.A.; Chin S.C.; Alitheen N.J.; Abdullah N.; Wan H.Y.
Published: (2012)

Isolation and identification of lactic acid bacteria from different stages of traditional Malaysian tempeh production
by: Pisol B.; Abdullah N.; Khalil K.A.; Nuraida L.
Published: (2015)

Isolation and characterisation of probiotic lactic acid bacteria from Malaysian fermented shrimp product pekasam senek
by: Alysha D.H.A.H.; Ilyanie H.Y.; Muryany I.M.Y.
Published: (2024)

Production of lactic acid from glycerol via chemical conversion using solid catalyst: A review
by: 2-s2.0-85021972648
Published: (2017)

Peptide cross-linked poly (Ethylene glycol) hydrogel films as biosensor coatings for the detection of collagenase
by: Ahmad N.; Colak B.; Zhang D.-W.; Gibbs M.J.; Watkinson M.; Remzi Becer C.; Gautrot J.E.; Krause S.
Published: (2019)

Negotiating Price in the Elopement of the Sasak Culture: Politeness Acts in Disagreeing
by: 2-s2.0-85178268146
Published: (2023)

Anti-invasion activities of heat-killed lactic acid bacteria isolates against Salmonella enterica serovar Typhimurium
by: Adzuan, et al.
Published: (2024)

Nasal vestibulitis—A potentially disastrous complication
by: 2-s2.0-85190723298
Published: (2024)

Environmental life cycle assessment of different biorefinery platforms valorizing municipal solid waste to bioenergy, microbial protein, lactic and succinic acid
by: 2-s2.0-85073688140
Published: (2020)

Emphysematous pyelonephritis: A rare complication of staghorn calculi
by: 2-s2.0-84986302328
Published: (2016)

Oxidative stress in human reproduction: Shedding light on a complicated Phenomenon
by: Agarwal A.; Sharma R.; Gupta S.; Harlev A.; Ahmad G.; du Plessis S.S.; Esteves S.C.; Wang S.M.; Durairajanayagam D.
Published: (2017)

Awareness and knowledge of tpo (act 172) among construction industry professionals and local planning authority personnel in klang valley
by: 2-s2.0-85072067507
Published: (2019)

Synthesis and conductivity studies of poly(Methyl methacrylate) (pmma) by co-polymerization and blending with polyaniline (pani)
by: Abu Hassan Shaari H.; Ramli M.M.; Mohtar M.N.; Abdul Rahman N.; Ahmad A.
Published: (2021)

Optimization and lubrication properties of Malaysian crude palm oil fatty acids based neopentyl glycol diester green biolubricant
by: 2-s2.0-85140253808
Published: (2022)

Retraction note: pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation (Drug Delivery and Translational Research, (2019), 9, 2, (555-577), 10.1007/s13346-018-0486-8)
by: 2-s2.0-85190274682
Published: (2024)

A case series of forearm compartment syndrome complicating transradial cardiac catheterization
by: Khirul Ashar N.A.; Ismail I.I.; Lingam R.; Mazlan N.F.; Azmi N.S.
Published: (2024)

Thermal properties of blends comprising poly(3-hydroxybutyrate-co-3- hydroxyvalerate) and epoxidized natural rubber
by: 2-s2.0-70449521208
Published: (2009)

A Review of the Prevalence of Thromboembolic Complications among Pregnant Women Infected with COVID-19
by: 2-s2.0-85139779648
Published: (2022)

Molecular dynamics simulations of glycyrrhizic acid aggregates as drug-carriers for paclitaxel
by: 2-s2.0-85073116171
Published: (2019)

Performance analysis of the energy consumption of the scheduling algorithms in long term evolution LTE (long term evolution) networks
by: Yusoff N.M.; Ali D.M.; Noh K.S.S.K.M.
Published: (2016)

The Effect of Poly(butylene adipate-co-terephthalate) (PBAT)/ Oil Palm Frond (OPF) Composite with Palm Stearin as Compatibiliser
by: Subuki I.; Azrin M.D.Z.; Ali A.A.M.; Hanipah S.H.; Ramlee N.A.
Published: (2025)

The Effect of Poly(butylene adipate-co-terephthalate) (PBAT)/ Oil Palm Frond (OPF) Composite with Palm Stearin as Compatibiliser
by: 2-s2.0-85215702999
Published: (2025)

An Unusual Delayed Complication of Rib Graft Microtia Reconstruction After Two Decades: A Case Report
by: Tuang G.J.; Mansor M.; Abdullah A.
Published: (2022)

Recent updates on novel approaches in insulin drug delivery: A review of challenges and pharmaceutical implications
by: 2-s2.0-85055902053
Published: (2018)

Research on the Long-tailed Distribution of Data in Bee Tracking
by: 2-s2.0-85219167939
Published: (2025)

Suppression of Coffee-Ring Effect on Nitrocellulose Membrane: Effect of Polyethylene Glycol
by: Shahruddin S.S.; Ideris N.; Kamarulzaman N.A.
Published: (2022)

PLAN-DO-CHECK-ACT CYCLE: A METHOD TO IMPROVE CUSTOMER SATISFACTION AT A MUNICIPAL COUNCIL IN MALAYSIA; [CICLO PLAN-DO-CHECK-ACT: UM MÉTODO PARA MELHORAR A SATISFAÇÃO DO CLIENTE EM UM CONSELHO MUNICIPAL NA MALÁSIA]; [CICLO PLANEAR-HACER-VERIFICAR-ACTUAR: UN MÉTODO PARA MEJORAR LA SATISFACCIÓN DEL CLIENTE EN UN CONCEJO MUNICIPAL EN MALASIA]
by: Zailani Q.N.N.; Sundram V.P.K.; Ibrahim I.; Senathirajah A.R.S.
Published: (2023)

CO2 utilization: Turning greenhouse gas into fuels and valuable products
by: 2-s2.0-85077990671
Published: (2020)

Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2
by: Hanafi N.I.; Mohamed A.S.; Md Noor J.; Abdul Hamid Hasani N.; Siran R.; Osman N.J.; Ab Rahim S.; Sheikh Abdul Kadir S.H.
Published: (2016)

Thermal, Conductivity and Molecular Interaction Studies of Poly(ethylene oxide)/Poly(methyl acrylate) Solid Polymer Electrolytes
by: Halim S.I.A.; Chan C.H.; Winie T.
Published: (2017)

Co-pyrolysis of palm kernel shell and discarded medical bottle for biofuel production: Synergistic effect and product distribution
by: 2-s2.0-85187200280
Published: (2024)

Thermal Behaviour of Hybrid Nanofluids in Water: Bio Glycol Mixture in Cooling Plates of PEMFC
by: Johari M.N.I.; Zakaria I.A.; Affendy N.S.M.
Published: (2022)

Catalytic hydrogenolysis of sorbitol to glycols over chromium oxide silica: Effect of chromium loading
by: 2-s2.0-85189180978
Published: (2024)

The tale of two vessels, vascular complications following a breach of the pelvic inner table due to acetabular screws: a report of two cases
by: 2-s2.0-85100126841
Published: (2021)

Corporate governance and default risk in long-term conventional bonds and sukuk in Malaysia
by: 2-s2.0-84989907979
Published: (2016)

A review for key challenges of the development of biodiesel industry
by: 2-s2.0-85061833628
Published: (2019)

Occlusal re-establishment and clinical complications of resin-bonded fixed partial dental prostheses cemented at an increased occlusal vertical dimension: A retrospective study
by: 2-s2.0-85097420136
Published: (2022)

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers
by: 2-s2.0-85089817995
Published: (2020)

Drug safety in Malaysia
by: Elkalmi R.M.; Al-Worafi Y.M.; Alseragi W.M.; Ming L.C.; Siddique A.
Published: (2020)