Enhanced oral bioavailability of astaxanthin with droplet size reduction
Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influ...
| 出版年: | Food Science and Technology Research |
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| 第一著者: | |
| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
2012
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| オンライン･アクセス: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869786588&doi=10.3136%2ffstr.18.549&partnerID=40&md5=5193b794043107b916ba56d36bd158c4 |
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Meor Mohd Affandi M.M.R.; Julianto T.; Majeed A.B.A. |
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| spelling |
Meor Mohd Affandi M.M.R.; Julianto T.; Majeed A.B.A. 2-s2.0-84869786588 Enhanced oral bioavailability of astaxanthin with droplet size reduction 2012 Food Science and Technology Research 18 4 10.3136/fstr.18.549 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869786588&doi=10.3136%2ffstr.18.549&partnerID=40&md5=5193b794043107b916ba56d36bd158c4 Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion an oil solution formulation. The nanosized emulsion shows increased Cmax and AUC0∞ and decreased Tmax values with a reduction of the emulsion globule size. The AUC0∞ of nanosized compared to macrosized emulsion and oil solution was increased by 110% - 140% and 140% - 200% respectively. 13446606 English Article All Open Access; Bronze Open Access |
| author |
2-s2.0-84869786588 |
| spellingShingle |
2-s2.0-84869786588 Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| author_facet |
2-s2.0-84869786588 |
| author_sort |
2-s2.0-84869786588 |
| title |
Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| title_short |
Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| title_full |
Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| title_fullStr |
Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| title_full_unstemmed |
Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| title_sort |
Enhanced oral bioavailability of astaxanthin with droplet size reduction |
| publishDate |
2012 |
| container_title |
Food Science and Technology Research |
| container_volume |
18 |
| container_issue |
4 |
| doi_str_mv |
10.3136/fstr.18.549 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869786588&doi=10.3136%2ffstr.18.549&partnerID=40&md5=5193b794043107b916ba56d36bd158c4 |
| description |
Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion an oil solution formulation. The nanosized emulsion shows increased Cmax and AUC0∞ and decreased Tmax values with a reduction of the emulsion globule size. The AUC0∞ of nanosized compared to macrosized emulsion and oil solution was increased by 110% - 140% and 140% - 200% respectively. |
| publisher |
|
| issn |
13446606 |
| language |
English |
| format |
Article |
| accesstype |
All Open Access; Bronze Open Access |
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1828987883528126464 |