Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
Abstract: In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecul...
| 發表在: | Russian Journal of Bioorganic Chemistry |
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| 主要作者: | |
| 格式: | Article |
| 語言: | English |
| 出版: |
Pleiades Publishing
2020
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| 在線閱讀: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083967679&doi=10.1134%2fS1068162020020028&partnerID=40&md5=58d8204571e91024f097916229c5f6da |
| 總結: | Abstract: In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecules was ascertained by biofilm inhibition study against Escherichia coli and Bacillus subtilis. The results revealed that two of the compounds were rather active inhibitors of these two pathogenic bacterial strains. According to the hemolytic study, most of the new molecules are mildly cytotoxic and hence might be used as safe antibacterial agents. © 2020, Pleiades Publishing, Ltd. |
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| ISSN: | 10681620 |
| DOI: | 10.1134/S1068162020020028 |