Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides

Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides

Abstract: In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecul...

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发表在:Russian Journal of Bioorganic Chemistry
主要作者: 2-s2.0-85083967679
格式: 文件
语言:English
出版: Pleiades Publishing 2020
在线阅读:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083967679&doi=10.1134%2fS1068162020020028&partnerID=40&md5=58d8204571e91024f097916229c5f6da
id Muhammad A. Abbasi; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
spelling Muhammad A. Abbasi; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
2-s2.0-85083967679
Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
2020
Russian Journal of Bioorganic Chemistry
46
2
10.1134/S1068162020020028
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083967679&doi=10.1134%2fS1068162020020028&partnerID=40&md5=58d8204571e91024f097916229c5f6da
Abstract: In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecules was ascertained by biofilm inhibition study against Escherichia coli and Bacillus subtilis. The results revealed that two of the compounds were rather active inhibitors of these two pathogenic bacterial strains. According to the hemolytic study, most of the new molecules are mildly cytotoxic and hence might be used as safe antibacterial agents. © 2020, Pleiades Publishing, Ltd.
Pleiades Publishing
10681620
English
Article
author 2-s2.0-85083967679
spellingShingle 2-s2.0-85083967679
Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
author_facet 2-s2.0-85083967679
author_sort 2-s2.0-85083967679
title Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
title_short Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
title_full Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
title_fullStr Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
title_full_unstemmed Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
title_sort Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
publishDate 2020
container_title Russian Journal of Bioorganic Chemistry
container_volume 46
container_issue 2
doi_str_mv 10.1134/S1068162020020028
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083967679&doi=10.1134%2fS1068162020020028&partnerID=40&md5=58d8204571e91024f097916229c5f6da
description Abstract: In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecules was ascertained by biofilm inhibition study against Escherichia coli and Bacillus subtilis. The results revealed that two of the compounds were rather active inhibitors of these two pathogenic bacterial strains. According to the hemolytic study, most of the new molecules are mildly cytotoxic and hence might be used as safe antibacterial agents. © 2020, Pleiades Publishing, Ltd.
publisher Pleiades Publishing
issn 10681620
language English
format Article
accesstype
record_format scopus
collection Scopus
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