Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking
A comprehensive phytochemical analysis of the methanolic extract of Malaysian Piper sarmentosum was carried out utilizing a mass-based dereplication strategy coupled with a molecular networking approach. The dereplication analysis using SIRIUS software in conjunction with the GNPS platform yielded 6...
| 出版年: | Malaysian Journal of Chemistry |
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| 第一著者: | |
| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Malaysian Institute of Chemistry
2025
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| オンライン･アクセス: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219069790&doi=10.55373%2fmjchem.v27i1.36&partnerID=40&md5=7b059fd38829bdacdab220359f8ba0fb |
| id |
Salmin N.N.; Rasol N.E.; Adib A.M.; Abdullah F.; Kiong L.S.; Khamis S.; Ismail N.H. |
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| spelling |
Salmin N.N.; Rasol N.E.; Adib A.M.; Abdullah F.; Kiong L.S.; Khamis S.; Ismail N.H. 2-s2.0-85219069790 Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking 2025 Malaysian Journal of Chemistry 27 1 10.55373/mjchem.v27i1.36 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219069790&doi=10.55373%2fmjchem.v27i1.36&partnerID=40&md5=7b059fd38829bdacdab220359f8ba0fb A comprehensive phytochemical analysis of the methanolic extract of Malaysian Piper sarmentosum was carried out utilizing a mass-based dereplication strategy coupled with a molecular networking approach. The dereplication analysis using SIRIUS software in conjunction with the GNPS platform yielded 62 compounds in the extract, including 30 amide alkaloids, 7 phenylpropanoids, 6 lignans, 6 monoacylglycerols, 9 flavonoids, 2 coumarins, 1 terpene and 1 benzofuran. The LCMS phytochemical profile was verified using seven isolated compounds, namely γ-asarone 1, trans-asarone 2, cepharanone B 3, sarmentosine 4, N-[3-(4methoxyphenyl)propanoyl]pyrrole 5, N-(3-phenylpropanoyl)pyrrole 6, and andamanicin 7. Pyrrole alkaloids 5 and 6 are reported for the first time as constituents of the Malaysian species. These were selected as marker compounds for quantification analysis. The plant extract contained 13.30 µg/mg of 5 and 66.80 µg/mg of 6 through a validated HPLC assay. © 2025 Malaysian Institute of Chemistry. All rights reserved. Malaysian Institute of Chemistry 15112292 English Article |
| author |
2-s2.0-85219069790 |
| spellingShingle |
2-s2.0-85219069790 Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| author_facet |
2-s2.0-85219069790 |
| author_sort |
2-s2.0-85219069790 |
| title |
Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| title_short |
Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| title_full |
Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| title_fullStr |
Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| title_full_unstemmed |
Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| title_sort |
Comprehensive Phytochemical Profiling of Malaysian Piper sarmentosum Leaves using Mass-Based Dereplication and Molecular Networking |
| publishDate |
2025 |
| container_title |
Malaysian Journal of Chemistry |
| container_volume |
27 |
| container_issue |
1 |
| doi_str_mv |
10.55373/mjchem.v27i1.36 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219069790&doi=10.55373%2fmjchem.v27i1.36&partnerID=40&md5=7b059fd38829bdacdab220359f8ba0fb |
| description |
A comprehensive phytochemical analysis of the methanolic extract of Malaysian Piper sarmentosum was carried out utilizing a mass-based dereplication strategy coupled with a molecular networking approach. The dereplication analysis using SIRIUS software in conjunction with the GNPS platform yielded 62 compounds in the extract, including 30 amide alkaloids, 7 phenylpropanoids, 6 lignans, 6 monoacylglycerols, 9 flavonoids, 2 coumarins, 1 terpene and 1 benzofuran. The LCMS phytochemical profile was verified using seven isolated compounds, namely γ-asarone 1, trans-asarone 2, cepharanone B 3, sarmentosine 4, N-[3-(4methoxyphenyl)propanoyl]pyrrole 5, N-(3-phenylpropanoyl)pyrrole 6, and andamanicin 7. Pyrrole alkaloids 5 and 6 are reported for the first time as constituents of the Malaysian species. These were selected as marker compounds for quantification analysis. The plant extract contained 13.30 µg/mg of 5 and 66.80 µg/mg of 6 through a validated HPLC assay. © 2025 Malaysian Institute of Chemistry. All rights reserved. |
| publisher |
Malaysian Institute of Chemistry |
| issn |
15112292 |
| language |
English |
| format |
Article |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1828987857589501952 |