Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients
BACKGROUND:: Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine catabolic enzyme involved in the initial and rate-limiting step of the catabolic pathway of toxic metabolites of 5-fluorouracil (5-FU). Several studies have reported that deficiency of DPD and polymorphisms of its gene are related to...
| 发表在: | Therapeutic Drug Monitoring |
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| 主要作者: | |
| 格式: | 文件 |
| 语言: | English |
| 出版: |
2013
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| 在线阅读: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885023351&doi=10.1097%2fFTD.0b013e318290acd2&partnerID=40&md5=ba55042f4bf5b85b4800c13ea9480b73 |