Exploring β-carboline hybrids and their derivatives: A review on synthesis and anticancer efficiency
(3-Carboline is a crucial compound in medicinal chemistry known for its versatile pharmacological activities. Recent research has focused on hybrid molecules incorporating a (3-carboline scaffold linked to other pharmacophore moieties. These hybrid compounds have demonstrated diverse therapeutic pro...
| Published in: | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
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| Main Authors: | , , , , , , |
| Format: | Review |
| Language: | English |
| Published: |
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
2025
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| Subjects: | |
| Online Access: | https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001432422300001 |
| Summary: | (3-Carboline is a crucial compound in medicinal chemistry known for its versatile pharmacological activities. Recent research has focused on hybrid molecules incorporating a (3-carboline scaffold linked to other pharmacophore moieties. These hybrid compounds have demonstrated diverse therapeutic properties, including anticancer, antianxiety, antimalarial, antidepressant, anti-inflammatory, antileishmanial, and antioxidant effects. This review highlights studies conducted from 2014 to the present with a particular emphasis on the development of (3-carboline hybrid compounds and their derivatives as potent anticancer agents. The structure-activity relationship (SAR) analysis reveals that these hybrids exhibit significant cytotoxicity against various cancer cell lines. This review aims to inspire further research into the novel synthesis and evolution of (3-carboline hybrids and their derivatives, potentially leading to new therapeutic advancements. |
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| ISSN: | 0223-5234 1768-3254 |
| DOI: | 10.1016/j.ejmech.2025.117412 |