Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

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Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

A new series of oxadiazole with thiadiazole moiety (6–27) were synthesized, characterized by different spectroscopic techniques and evaluated for β-glucuronidase inhibitory potential. Sixteen analogs such as 6, 7, 8, 9, 10, 12, 13, 14, 17, 18, 20, 23, 24, 25, 26 and 27 showed IC50 values in the rang...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Bioorganic and Medicinal Chemistry
المؤلف الرئيسي:	Taha M.; Imran S.; Alomari M.; Rahim F.; Wadood A.; Mosaddik A.; Uddin N.; Gollapalli M.; Alqahtani M.A.; Bamarouf Y.A.
التنسيق:	مقال
اللغة:	English
منشور في:	Elsevier Ltd 2019
الوصول للمادة أونلاين:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066996057&doi=10.1016%2fj.bmc.2019.05.049&partnerID=40&md5=ecd950b1a53d346832bbb97fc0a2db8b

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