Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

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Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study

A new series of oxadiazole with thiadiazole moiety (6–27) were synthesized, characterized by different spectroscopic techniques and evaluated for β-glucuronidase inhibitory potential. Sixteen analogs such as 6, 7, 8, 9, 10, 12, 13, 14, 17, 18, 20, 23, 24, 25, 26 and 27 showed IC50 values in the rang...

書誌詳細
出版年:	Bioorganic and Medicinal Chemistry
第一著者:	Taha M.; Imran S.; Alomari M.; Rahim F.; Wadood A.; Mosaddik A.; Uddin N.; Gollapalli M.; Alqahtani M.A.; Bamarouf Y.A.
フォーマット:	論文
言語:	English
出版事項:	Elsevier Ltd 2019
オンライン･アクセス:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066996057&doi=10.1016%2fj.bmc.2019.05.049&partnerID=40&md5=ecd950b1a53d346832bbb97fc0a2db8b

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