Synthesis of novel 3,4-fused pyrazolidinone γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines

A new pathway for the synthesis of novel 3,4-fused pyrazolidinone γ-lactam (4) starting from 2,3- dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and i...

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Bibliographic Details
Published in:Organic Communications
Main Author: Rashid F.N.A.A.; Mohammat M.F.; Shaameri Z.; Hamzah A.S.
Format: Article
Language:English
Published: ACG Publications 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072658758&doi=10.25135%2facg.oc.62.19.07.1323&partnerID=40&md5=3c928e76eac195ed8cdaf1e63c53fead