CRL4Cdt2 Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA
The ubiquitin ligase CRL4Cdt2 plays a vital role in preserving genomic integrity by regulating essential proteins during S phase and after DNA damage. Deregulation of CRL4Cdt2 during the cell cycle can cause DNA re-replication, which correlates with malignant transformation and tumor growth. CRL4Cdt...
| Published in: | Genes |
|---|---|
| Main Author: | |
| Format: | Review |
| Language: | English |
| Published: |
MDPI
2022
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124080113&doi=10.3390%2fgenes13020266&partnerID=40&md5=3714856ad58aedf377ef8b0c7148734f |