CRL4Cdt2 Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA

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CRL4Cdt2 Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA

The ubiquitin ligase CRL4Cdt2 plays a vital role in preserving genomic integrity by regulating essential proteins during S phase and after DNA damage. Deregulation of CRL4Cdt2 during the cell cycle can cause DNA re-replication, which correlates with malignant transformation and tumor growth. CRL4Cdt...

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Bibliographic Details
Published in:	Genes
Main Author:	Mazian M.A.; Yamanishi K.; Rahman M.Z.A.; Ganasen M.; Nishitani H.
Format:	Review
Language:	English
Published:	MDPI 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124080113&doi=10.3390%2fgenes13020266&partnerID=40&md5=3714856ad58aedf377ef8b0c7148734f

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