Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment

QR Code

Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment

Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and antioxidants has been established as an important factor that can negatively affect the outcomes of assisted reproductive techniques (ARTs). Excess ROS exert their pathological effects through damage to cellular lipi...

Full description

Bibliographic Details
Published in:	Antioxidants
Main Author:	Agarwal A.; Rosas I.M.; Anagnostopoulou C.; Cannarella R.; Boitrelle F.; Munoz L.V.; Finelli R.; Durairajanayagam D.; Henkel R.; Saleh R.
Format:	Review
Language:	English
Published:	MDPI 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125285263&doi=10.3390%2fantiox11030477&partnerID=40&md5=e7008efcbc51efa21ddef0bfd5227525

Similar Items

Sperm epigenetics landscape: correlation with embryo quality, reproductive outcomes and offspring’s health
by: Garrido N.; Boitrelle F.; Saleh R.; Durairajanayagam D.; Colpi G.; Agarwal A.
Published: (2023)

Oxidative stress in human reproduction: Shedding light on a complicated Phenomenon
by: Agarwal A.; Sharma R.; Gupta S.; Harlev A.; Ahmad G.; du Plessis S.S.; Esteves S.C.; Wang S.M.; Durairajanayagam D.
Published: (2017)

Reactive oxygen species and male reproductive hormones
by: Darbandi M.; Darbandi S.; Agarwal A.; Sengupta P.; Durairajanayagam D.; Henkel R.; Sadeghi M.R.
Published: (2018)

A scientometric analysis of research publications on male infertility and assisted reproductive technology
by: Agarwal A.; Panner Selvam M.K.; Baskaran S.; Finelli R.; Leisegang K.; Barbăroșie C.; Pushparaj P.N.; Robert K.A.; Ambar R.; Iovine C.; Durairajanayagam D.; Henkel R.
Published: (2021)

Stress and how it affects reproduction
by: 2-s2.0-33645686138
Published: (2006)

Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
by: Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
Published: (2023)

Lifestyle Factors and Reproductive Health
by: Agarwal A.; Durairajanayagam D.
Published: (2015)

Need for Training in Research Methodology Prior to Conducting Systematic Reviews and Meta-Analyses, and the Effectiveness of an Online Training Program: The Global Andrology Forum Model
by: Cannarella R.; Shah R.; Boitrelle F.; Saleh R.; Durairajanayagam D.; Harraz A.M.; Agarwal A.
Published: (2023)

Are men talking their reproductive health away?
by: Agarwal A.; Durairajanayagam D.
Published: (2015)

A web-based global educational model for training in semen analysis during the covid-19 pandemic
by: Agarwal A.; Finelli R.; Durairajanayagam D.; Leisegang K.; Sharma R.; Gupta S.; Singh N.; Belo A.; Darbandi M.; Madani S.; Covarrubias S.; Darbandi S.; Sadeghi R.; Pompeu C.; Boitrelle F.; Kandil H.; Saleh R.; Arafa M.; Vogiatzi P.; Rosas I.M.; Anagnostopoulou C.; Chockalingam A.; Wirka K.A.; Sallam H.N.; Shah R.; Henkel R.
Published: (2021)

A global survey of reproductive specialists to determine the clinical utility of oxidative stress testing and antioxidant use in male infertility
by: Agarwal A.; Finelli R.; Panner Selvam M.K.; Leisegang K.; Majzoub A.; Tadros N.; Ko E.; Parekh N.; Henkel R.; Durairajanayagam D.; Colpi G.M.; Cho C.-L.; Sallam H.N.; Park H.J.; Saleh R.; Micic S.; Ambar R.F.; Zini A.; Tremellen K.; Alvarez J.G.; Palani A.; Arafa M.; Gava M.M.; Jindal S.; Amar E.; Kopa Z.; Moein M.-R.; Busetto G.M.; Sengupta P.; Kavoussi P.; Maldonado I.; Fikri J.; Borges E., et al.
Published: (2021)

Oxidative stress, testicular inflammatory pathways, and male reproduction
by: 2-s2.0-85115105953
Published: (2021)

Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
by: Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
Published: (2021)

Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update
by: Sadikan, et al.
Published: (2025)

Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation
by: Osman A.A.; Chin S.-F.; Teh L.-K.; Abdullah N.; Abdul Murad N.A.; Jamal R.
Published: (2025)

The Global Andrology Forum (GAF): A World-Wide, Innovative, Online Initiative to Bridge the Gaps in Research and Clinical Practice of Male Infertility and Sexual Health
by: Agarwal A.; Saleh R.; Boitrelle F.; Cannarella R.; Hamoda T.A.-A.A.-M.; Durairajanayagam D.; Harraz A.M.; Shah R.
Published: (2022)

Utility of antioxidants during assisted reproductive techniques: An evidence based review
by: Agarwal A.; Durairajanayagam D.; du Plessis S.S.
Published: (2014)

Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update
by: Sadikan M.Z.; Lambuk L.; Reshidan N.H.; Abdul Ghani N.A.; Ahmad A.I.; Ahmad Kamal M.S.; Lazaldin M.A.M.; Ahmad Hairi H.; Mohamud R.; Abdul Nasir N.A.
Published: (2025)

A systematic review of herbal medicine in the clinical treatment of benign prostatic hyperplasia
by: Leisegang K.; Jimenez M.; Durairajanayagam D.; Finelli R.; Majzoub A.; Henkel R.; Agarwal A.
Published: (2022)

Cleveland Clinic's summer research program in reproductive medicine: An inside look at the class of 2014
by: Durairajanayagam D.; Kashou A.H.; Tatagari S.; Vitale J.; Cirenza C.; Agarwal A.
Published: (2015)

Physical activity and male reproductive function
by: Hamim F.M.; Durairajanayagam D.; Daud S.B.; Singh H.J.
Published: (2025)

Introduction
by: Durairajanayagam D.; Agarwal A.; Henkel R.
Published: (2021)

Proteomics, oxidative stress and male infertility
by: Agarwal A.; Durairajanayagam D.; Halabi J.; Peng J.; Vazquez-Levin M.
Published: (2014)

A Systematic Review of the Effects of Bisphenol Analogs on Embryonic Development and Cytoskeletal Organization of Zebrafish (Danio rerio) Embryos
by: 2-s2.0-85127540514
Published: (2023)

Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
by: Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
Published: (2024)

ICSI for non-male factor infertility: time to reappraise IVF?
by: Sallam H.; Boitrelle F.; Palini S.; Durairajanayagam D.; Parmegiani L.; Jindal S.; Saleh R.; Colpi G.; Agarwal A.
Published: (2023)

Causes and consequences of sperm mitochondrial dysfunction
by: Durairajanayagam D.; Singh D.; Agarwal A.; Henkel R.
Published: (2021)

Virtual Reality for Stress Reduction: Usability Insights into Exposure Environments and Relaxation Therapy
by: 2-s2.0-85219512099
Published: (2024)

How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
by: Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
Published: (2023)

Role of Withania somnifera (Ashwagandha) in the management of male infertility
by: Sengupta P.; Agarwal A.; Pogrebetskaya M.; Roychoudhury S.; Durairajanayagam D.; Henkel R.
Published: (2018)

Highly cited articles in the field of male infertility and antioxidants: A scientometric analysis
by: Agarwal A.; Selvam M.K.P.; Baskaran S.; Finelli R.; Leisegang K.; Barbăroșie C.; Pushparaj P.N.; Robert K.A.; Ambar R.F.; Iovine C.; Durairajanayagam D.; Henkel R.
Published: (2021)

Reactive oxygen species and male reproductive hormones
by: 2-s2.0-85053186982
Published: (2018)

Vitamin E as an antioxidant in female reproductive health
by: 2-s2.0-85041372181
Published: (2018)

Sperm morphology assessment in the era of intracytoplasmic sperm injection: Reliable results require focus on standardization, quality control, and training
by: Agarwal A.; Sharma R.; Gupta S.; Finelli R.; Parekh N.; Selvam M.K.P.; Henkel R.; Durairajanayagam D.; Pompeu C.; Madani S.; Belo A.; Singh N.; Covarrubias S.; Darbandi S.; Sadeghi R.; Darbandi M.; Vogiatzi P.; Boitrelle F.; Simopoulou M.; Saleh R.; Arafa M.; Majzoub A.; Kandil H.; Zini A.; Ko E.; Alvarez J.G.; Martinez M.; Ramsay J.; Jindal S.; Busetto G.M.; Sallam H.; Maldonado I.; Anagnostopoulou C.; Alves M.G.; Sengupta P.; Gilany K.; Evenson D.P.; Lewis S.E.M.; Gosalvez J.; Ambar R.F.; Shah R.
Published: (2021)

Comprehensive Analysis of Global Research on Human Varicocele: A Scientometric Approach
by: Agarwal A.; Finelli R.; Durairajanayagam D.; Leisegang K.; Henkel R.; Salvio G.; Aghamajidi A.; Sengupta P.; Crisóstomo L.; Tsioulou P.A.; Roychoudhury S.; Finocchi F.; Darbandi M.; Mottola F.; Darbandi S.; Iovine C.; Santonastaso M.; Zaker H.; Kumar Kesari K.; Nomanzadeh A.; Gugnani N.; Rambhatla A.; Duran M.B.; Ceyhan E.; Kandil H.; Arafa M.; Saleh R.; Shah R.; Ko E.; Boitrelle F.
Published: (2022)

Stress at the Helm: the Prevalence and Key Risk Factors of Occupational Stress Among Port Workers in the Port Terminal Industry
by: Yaakub N.; Razak N.F.A.; Baharuddin M.R.; Noor M.A.M.
Published: (2024)

An online educational model in andrology for student training in the art of scientific writing in the COVID-19 pandemic
by: Agarwal A.; Leisegang K.; Panner Selvam M.K.; Durairajanayagam D.; Barbarosie C.; Finelli R.; Sengupta P.; Dutta S.; Majzoub A.; Pushparaj P.N.; Elbardisi H.; Sharma R.; Gupta S.; Arafa M.; Roychoudhury S.; Alves M.G.; Oliveira P.F.; Henkel R.
Published: (2021)

Effect of APC on killing of staphylococcus aureus by oxidative stress agents
by: Abdullah N.F.; Mohamad Hussain R.; Amom Z.
Published: (2016)

Virtual desktop environment on Cloud computing platform
by: Fuzi M.F.M.; Hamid R.S.; Ahmad M.A.
Published: (2014)

Visual art approach to promoting Malaysia’s art and cultural heritage overseas
by: Basaree R.O.; Legino R.; Ahmad M.Y.
Published: (2016)