Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3

Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3

Ternatin-family cyclic peptides inhibit protein synthesis by targeting the eukaryotic elongation factor-1α. A potentially related cytotoxic natural product (‘A3’) was isolated from Aspergillus, but only 4 of its 11 stereocentres could be assigned. Here, we synthesized SR-A3 and SS-A3—two out of 128...

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Bibliographic Details
Published in:Nature Chemistry
Main Author: Wang H.-Y.; Yang H.; Holm M.; Tom H.; Oltion K.; Al-Khdhairawi A.A.Q.; Weber J.-F.F.; Blanchard S.C.; Ruggero D.; Taunton J.
Format: Article
Language:English
Published: Nature Research 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138252320&doi=10.1038%2fs41557-022-01039-3&partnerID=40&md5=44c9a7f870825e1eb27788b958447242

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138252320&doi=10.1038%2fs41557-022-01039-3&partnerID=40&md5=44c9a7f870825e1eb27788b958447242

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