Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes

Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes

Male infertility is attributed to multiple factors including high levels of sperm DNA fragmentation (SDF). Conventional semen analysis continues to be the gold standard for diagnosis of male factor infertility around the world. However, the limitations of basic semen analysis have prompted the searc...

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书目详细资料
发表在:Panminerva Medica
主要作者: Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
格式: Review
语言:English
出版: Edizioni Minerva Medica 2023
在线阅读:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255480&doi=10.23736%2fS0031-0808.23.04836-X&partnerID=40&md5=9c5cd3252df25319f3412516ee87b98a
实物特征
总结:Male infertility is attributed to multiple factors including high levels of sperm DNA fragmentation (SDF). Conventional semen analysis continues to be the gold standard for diagnosis of male factor infertility around the world. However, the limitations of basic semen analysis have prompted the search for complementary assessments of sperm function and integrity. Sperm DNA fragmentation assays (direct or indirect) are emerging as important diagnostic tools in male infertility workups, and have been advocated for use in infertile couples for a variety of reasons. While a controlled degree of DNA nicking is required for appropriate DNA compaction, excessive fragmentation of sperm DNA is linked to impaired male fertility potential, decreased fertilization, poor embryo quality, recurrent pregnancy loss, and failure of assisted reproductive technology procedures. However, there is an ongoing debate regarding whether or not to employ SDF as a routine test for male infertility. This review compiles up-to-date information regarding the pathophysiology of SDF, the currently available SDF tests, and the role of SDF tests in natural and assisted conception conditions. © 2023 EDIZIONI MINERVA MEDICA.
ISSN:310808
DOI:10.23736/S0031-0808.23.04836-X

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