Insight into the Structure and Physicochemical Properties of Potent Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer’s Disease Drugs
Background: In Alzheimer’s Disease (AD), chemokines recruit pro-inflammatory me-diators and increase the aggregation of both Aβ (amyloid-β) plaque and neurofibrillary tangles (NFTs). Chemokine receptor 5 (CCR5) has been demonstrated to be involved in neuroinflamma-tion and neuroimmunology, where its...
| Published in: | Central Nervous System Agents in Medicinal Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Bentham Science Publishers
2023
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172425864&doi=10.2174%2f1871524923666230726102846&partnerID=40&md5=b745acb10d4f6855f36774a6a420297f |