Insight into the Structure and Physicochemical Properties of Potent Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer’s Disease Drugs

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Insight into the Structure and Physicochemical Properties of Potent Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer’s Disease Drugs

Background: In Alzheimer’s Disease (AD), chemokines recruit pro-inflammatory me-diators and increase the aggregation of both Aβ (amyloid-β) plaque and neurofibrillary tangles (NFTs). Chemokine receptor 5 (CCR5) has been demonstrated to be involved in neuroinflamma-tion and neuroimmunology, where its...

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Bibliographic Details
Published in:	Central Nervous System Agents in Medicinal Chemistry
Main Author:	Yusof N.I.S.M.; Awaluddin N.A.; Fauzi F.M.
Format:	Article
Language:	English
Published:	Bentham Science Publishers 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172425864&doi=10.2174%2f1871524923666230726102846&partnerID=40&md5=b745acb10d4f6855f36774a6a420297f

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