Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach
This research is based on the synthesis, characterization and in vitro α-glucosidase inhibitory activity of fourteen amides (2 a–2 n) of flurbiprofen drug. Seven compounds in the series displayed potent inhibitory activity having IC50 values (IC50=5.67±0.89 μM) to (IC50=17.87±2.39 μM) in comparison...
| 發表在: | ChemistrySelect |
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| 主要作者: | |
| 格式: | Article |
| 語言: | English |
| 出版: |
John Wiley and Sons Inc
2024
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| 在線閱讀: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191891273&doi=10.1002%2fslct.202401296&partnerID=40&md5=ae0c3acea5a089c81db3f5131dce9fdd |