Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights

A new series of multifunctional amides has been synthesized having moderate enzyme inhibitory potentials and mild cytotoxicity. 2-Furyl(1-piperazinyl)methanone (1) was coupled with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) to form {4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2...

詳細記述

書誌詳細
出版年:Journal of Theoretical Biology
第一著者: 2-s2.0-85053905014
フォーマット: 論文
言語:English
出版事項: Academic Press 2018
オンライン・アクセス:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053905014&doi=10.1016%2fj.jtbi.2018.09.018&partnerID=40&md5=389296c4a0639983b208beb994df0448