Virtual screening, ADME study, and molecular dynamic simulation of chalcone and flavone derivatives as 5-Lipoxygenase (5-LO) inhibitor
5-Lipoxygenase (5-LO) is one of the key enzymes involved in the production of pro-inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO is a promising therapeutic strategy against inflammation. Chalcones and flavones are known to have a broad spectrum of biolo...
| الحاوية / القاعدة: | Molecular Simulation |
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| المؤلف الرئيسي: | |
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Taylor and Francis Ltd.
2020
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| الوصول للمادة أونلاين: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081355590&doi=10.1080%2f08927022.2020.1732961&partnerID=40&md5=97bf92718564f71310f070f465f5383e |