Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies

Bis-thiobarbiturate derivatives 1-15 have been synthesized, characterized by 1HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC50 values ranging 7.45 ± 0.12 - 74.24 ± 0.81 μmol/L while the standard thiourea behaved normally (...

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发表在:Chinese Chemical Letters
主要作者: 2-s2.0-84960192729
格式: 文件
语言:English
出版: Elsevier 2016
在线阅读:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960192729&doi=10.1016%2fj.cclet.2015.12.035&partnerID=40&md5=811cfe660bde2a5cdcd83e2b4571e983